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2016 ; 1
(1
): 6-17
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The Silent Epidemic - Frailty and Aging with HIV
#MMPMID28386608
Willig AL
; Overton ET
; Saag MS
Total Patient Care HIV HCV
2016[]; 1
(1
): 6-17
PMID28386608
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As the number of older adults with HIV increases, this population is experiencing
an increased risk for frailty. While there is no single definition or diagnostic
criteria for frailty, it is generally recognized as an accumulation of deficits
in functional capacity and ability to perform activities of daily living. Frailty
may be present in up to half of older adults living with HIV, and is associated
with significant morbidity and mortality risk in this group. Frailty in HIV can
either be transient, and linked to the status of HIV infection, or resemble a
more typical gradual decline in functional capacity. Frailty risk in HIV may be
exacerbated by mitochondrial dysfunction, chronic inflammation, and oxidative
stress. Several tools have been developed and adapted to assess different domains
of frailty, yet medical treatment of this condition can be complex and should
consider management of polypharmacy as well as nutrition and exercise
interventions. However, few concrete strategies have been developed to prevent or
treat frailty in the context of HIV infection. This review summarizes what is
currently known about the prevalence, diagnosis, and management of frailty among
older adults living with HIV.
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