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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Biochem+Soc+Trans
2016 ; 44
(1
): 279-85
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English Wikipedia
Inositol polyphosphate multikinase (IPMK) in transcriptional regulation and
nuclear inositide metabolism
#MMPMID26862216
Malabanan MM
; Blind RD
Biochem Soc Trans
2016[Feb]; 44
(1
): 279-85
PMID26862216
show ga
Inositol polyphosphate multikinase (IPMK, ipk2, Arg(82), ArgRIII) is an inositide
kinase with unusually flexible substrate specificity and the capacity to partake
in many functional protein-protein interactions (PPIs). By merging these two
activities, IPMK is able to execute gene regulatory functions that are very
unique and only now beginning to be recognized. In this short review, we present
a brief history of IPMK, describe the structural biology of the enzyme and
highlight a few recent discoveries that have shed more light on the role IPMK
plays in inositide metabolism, nuclear signalling and transcriptional regulation.