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10.1073/pnas.1620954114 http://scihub22266oqcxt.onion/10.1073/pnas.1620954114 C5380102!5380102!28289191     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Proc+Natl+Acad+Sci+U+S+A 2017 ; 114 (13): E2748-57 Nephropedia Template TP {{tp|p=28289191|t=2017. Cathepsin S is the major activator of the psoriasis-associated proinflammatory cytokine IL-36? |pdf=|usr=}}{{28289191}} gab.com Text Cathepsin S is the major activator of the psoriasis-associated proinflammatory cytokine IL-36 JO: Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=28289191 #FOAvip IL-36? is a potent cytokine that drives and orchestrates inflammation. It is strongly expressed at barrier tissues such as the skin and thus is particularly relevant to inflammatory diseases that affect these tissues, including psoriasis. IL-36? is expressed as an inactive precursor that requires precise N-terminal truncation for activation. In these investigations, we demonstrate that cathepsin S is the major IL-36??activating protease expressed by barrier tissues. Moreover, we show that both cathepsin S and IL-36? are strongly up-regulated in psoriatic inflammation. These findings are important as they both identify the mechanism of IL-36? activation and highlight that this mechanism may play a central role in the development of psoriatic inflammation. Twit Text FOAVip Cathepsin S is the major activator of the psoriasis-associated proinflammatory cytokine IL-36 ????Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=28289191 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28289191 #FOAvip English Wikipedia <ref>{{Cite pmid|28289191}}</ref> Cathepsin S is the major activator of the psoriasis-associated proinflammatory cytokine IL-36? #MMPMID28289191 Ainscough JS; Macleod T; McGonagle D; Brakefield R; Baron JM; Alase A; Wittmann M; Stacey M Proc Natl Acad Sci U S A 2017[Mar]; 114 (13): E2748-57 PMID28289191show ga IL-36? is a potent cytokine that drives and orchestrates inflammation. It is strongly expressed at barrier tissues such as the skin and thus is particularly relevant to inflammatory diseases that affect these tissues, including psoriasis. IL-36? is expressed as an inactive precursor that requires precise N-terminal truncation for activation. In these investigations, we demonstrate that cathepsin S is the major IL-36??activating protease expressed by barrier tissues. Moreover, we show that both cathepsin S and IL-36? are strongly up-regulated in psoriatic inflammation. These findings are important as they both identify the mechanism of IL-36? activation and highlight that this mechanism may play a central role in the development of psoriatic inflammation. äCathepsin S is the major activator of the psoriasis-associated proinfl(epmc).pdf DeepDyve Pubget Overpricing