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10.1038/srep05967 http://scihub22266oqcxt.onion/10.1038/srep05967 C5380014!5380014!25095732     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Sci+Rep 2014 ; 4 (ä): ä Nephropedia Template TP {{tp|p=25095732|t=2014. ?2AP mediated myofibroblast formation and the development of renal fibrosis in unilateral ureteral obstruction |pdf=|usr=}}{{25095732}} gab.com Text 2AP mediated myofibroblast formation and the development of renal fibrosis in unilateral ureteral obstruction JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=25095732 #FOAvip Renal fibrosis is the final common pathway of a wide variety of chronic kidney diseases. Myofibroblast formation via the differentiation of from tissue-resident fibroblasts and bone marrow-derived mesenchymal stem cells (MSCs), and epithelial-to-mesenchymal transition (EMT) is known to play a pivotal role in the development of renal fibrosis. However, the detailed mechanisms underlying this disorder remain unclear. We herein investigated the role of alpha 2-antiplasmin (?2AP) in myofibroblast formation and the development of renal fibrosis. We observed the development of renal fibrosis using unilateral ureteral obstruction (UUO). ?2AP had accumulated in the UUO-induced obstructed kidneys and ?2AP deficiency attenuated UUO-induced renal fibrosis in mice. The degree of myofibroblast formation in the obstructed kidneys of ?2AP?/? mice was less than that in ?2AP+/+ mice. In vitro, ?2AP induced myofibroblast formation in renal tubular epithelial cells (RTECs), renal fibrosblasts, and bone marrow-derived mesenchymal stem cells (MSCs). ?2AP also induced the production of TGF-?, which is known to be a key regulator of myofibroblast formation and fibrosis. ?2AP-induced the TGF-? production was significantly reduced by SP600125, c-Jun N-terminal kinase (JNK) specific inhibitor. Our findings suggest that ?2AP induces myofibroblast formation in the obstructed kidneys, and mediates the development of renal fibrosis. Twit Text FOAVip 2AP mediated myofibroblast formation and the development of renal fibrosis in unilateral ureteral obstruction ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=25095732 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25095732 #FOAvip English Wikipedia <ref>{{Cite pmid|25095732}}</ref> ?2AP mediated myofibroblast formation and the development of renal fibrosis in unilateral ureteral obstruction #MMPMID25095732 Kanno Y; Kawashita E; Kokado A; Kuretake H; Ikeda K; Okada K; Seishima M; Ueshima S; Matsuo O; Matsuno H Sci Rep 2014[]; 4 (ä): ä PMID25095732show ga Renal fibrosis is the final common pathway of a wide variety of chronic kidney diseases. Myofibroblast formation via the differentiation of from tissue-resident fibroblasts and bone marrow-derived mesenchymal stem cells (MSCs), and epithelial-to-mesenchymal transition (EMT) is known to play a pivotal role in the development of renal fibrosis. However, the detailed mechanisms underlying this disorder remain unclear. We herein investigated the role of alpha 2-antiplasmin (?2AP) in myofibroblast formation and the development of renal fibrosis. We observed the development of renal fibrosis using unilateral ureteral obstruction (UUO). ?2AP had accumulated in the UUO-induced obstructed kidneys and ?2AP deficiency attenuated UUO-induced renal fibrosis in mice. The degree of myofibroblast formation in the obstructed kidneys of ?2AP?/? mice was less than that in ?2AP+/+ mice. In vitro, ?2AP induced myofibroblast formation in renal tubular epithelial cells (RTECs), renal fibrosblasts, and bone marrow-derived mesenchymal stem cells (MSCs). ?2AP also induced the production of TGF-?, which is known to be a key regulator of myofibroblast formation and fibrosis. ?2AP-induced the TGF-? production was significantly reduced by SP600125, c-Jun N-terminal kinase (JNK) specific inhibitor. Our findings suggest that ?2AP induces myofibroblast formation in the obstructed kidneys, and mediates the development of renal fibrosis. ä?2AP mediated myofibroblast formation and the development of renal fib(epmc).pdf DeepDyve Pubget Overpricing