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10.1212/WNL.0000000000003796 http://scihub22266oqcxt.onion/10.1212/WNL.0000000000003796 C5379928!5379928!28258082     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Neurology 2017 ; 88 (14): 1340-8 Nephropedia Template TP {{tp|p=28258082|t=2017. DPPX antibody?associated encephalitis: Main syndrome and antibody effects |pdf=|usr=}}{{28258082}} gab.com Text DPPX antibody associated encephalitis: Main syndrome and antibody effects JO: Neurology http://www.kidney.de/pget.php?&tw=1&pmid=28258082 #FOAvip Objective:: To report the main syndrome of dipeptidyl-peptidase?like protein 6 (DPPX) antibody?associated encephalitis, immunoglobulin G (IgG) subclass, and the antibody effects on DPPX/Kv4.2 potassium channels. Methods:: A retrospective analysis of new patients and cases reported since 2013 was performed. IgG subclass and effects of antibodies on cultured neurons were determined with described techniques. Results:: Nine new patients were identified (median age 57 years, range 36?69 years). All developed severe prodromal weight loss or diarrhea followed by cognitive dysfunction (9), memory deficits (5), CNS hyperexcitability (8; hyperekplexia, myoclonus, tremor, or seizures), or brainstem or cerebellar dysfunction (7). The peak of the disease was reached 8 months (range 1?54 months) after onset. All patients had both IgG4 and IgG1 DPPX antibodies. In cultured neurons, the antibodies caused a decrease of DPPX clusters and Kv4.2 protein that was reversible on removal of the antibodies. Considering the current series and previously reported cases (total 39), 67% developed the triad: weight loss (median 20 kg; range 8?53 kg)/gastrointestinal symptoms, cognitive-mental dysfunction, and CNS hyperexcitability. Outcome was available from 35 patients (8 not treated with immunotherapy): 60% had substantial or moderate improvement, 23% had no improvement (most of them not treated), and 17% died. Relapses occurred in 8 of 35 patients (23%) and were responsive to immunotherapy. Conclusions:: DPPX antibodies are predominantly IgG1 and IgG4 and associate with cognitive-mental deficits and symptoms of CNS hyperexcitability that are usually preceded by diarrhea, other gastrointestinal symptoms, and weight loss. The disorder is responsive to immunotherapy, and this is supported by the reversibility of the antibody effects in cultured neurons. Twit Text FOAVip DPPX antibody associated encephalitis: Main syndrome and antibody effects ????Neurology http://www.kidney.de/pget.php?&tw=1&pmid=28258082 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28258082 #FOAvip English Wikipedia <ref>{{Cite pmid|28258082}}</ref> DPPX antibody?associated encephalitis: Main syndrome and antibody effects #MMPMID28258082 Hara M; Ariņo H; Petit-Pedrol M; Sabater L; Titulaer MJ; Martinez-Hernandez E; Schreurs MW; Rosenfeld MR; Graus F; Dalmau J Neurology 2017[Apr]; 88 (14): 1340-8 PMID28258082show ga Objective:: To report the main syndrome of dipeptidyl-peptidase?like protein 6 (DPPX) antibody?associated encephalitis, immunoglobulin G (IgG) subclass, and the antibody effects on DPPX/Kv4.2 potassium channels. Methods:: A retrospective analysis of new patients and cases reported since 2013 was performed. IgG subclass and effects of antibodies on cultured neurons were determined with described techniques. Results:: Nine new patients were identified (median age 57 years, range 36?69 years). All developed severe prodromal weight loss or diarrhea followed by cognitive dysfunction (9), memory deficits (5), CNS hyperexcitability (8; hyperekplexia, myoclonus, tremor, or seizures), or brainstem or cerebellar dysfunction (7). The peak of the disease was reached 8 months (range 1?54 months) after onset. All patients had both IgG4 and IgG1 DPPX antibodies. In cultured neurons, the antibodies caused a decrease of DPPX clusters and Kv4.2 protein that was reversible on removal of the antibodies. Considering the current series and previously reported cases (total 39), 67% developed the triad: weight loss (median 20 kg; range 8?53 kg)/gastrointestinal symptoms, cognitive-mental dysfunction, and CNS hyperexcitability. Outcome was available from 35 patients (8 not treated with immunotherapy): 60% had substantial or moderate improvement, 23% had no improvement (most of them not treated), and 17% died. Relapses occurred in 8 of 35 patients (23%) and were responsive to immunotherapy. Conclusions:: DPPX antibodies are predominantly IgG1 and IgG4 and associate with cognitive-mental deficits and symptoms of CNS hyperexcitability that are usually preceded by diarrhea, other gastrointestinal symptoms, and weight loss. The disorder is responsive to immunotherapy, and this is supported by the reversibility of the antibody effects in cultured neurons. äDPPX antibody?associated encephalitis: Main syndrome and antibody effe(epmc).pdf DeepDyve Pubget Overpricing