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2017 ; 8
(ä): 45865
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Comparison for Efficacy and Tolerability among Ten Drugs for Treatment of
Parkinson s Disease: A Network Meta-Analysis
#MMPMID28374775
Zhuo C
; Zhu X
; Jiang R
; Ji F
; Su Z
; Xue R
; Zhou Y
Sci Rep
2017[Apr]; 8
(ä): 45865
PMID28374775
show ga
Parkinson's disease (PD) is a long term disorder affects the central nervous
system and we aim to determine the relative efficacy of the current available
drugs used in PD. Firstly, we performed a systematic review in current literature
and eligible studies were retrieved from online databases, relevant data were
extracted. Efficacy of these medications was assessed by different Unified
Parkinson's Disease Rating Scales (UPDRS). Mean difference (MD) and odds ratio
(OR) were produced by pairwise or network meta-analysis (NMA). Finally, we
performed a cluster analysis for the included medications with respect to their
surface under the cumulative ranking curve (SUCRA). Pairwise meta-analysis
suggests that selegiline had a higher ranking in UPDRS II, UPDRS III and UPDRS
total than bromocriptine and levodopa. Selegiline was more tolerable than
bromocriptine (OR?=?0.62, CI: 0.39 to 0.98) and pramipexole was less tolerable
than levodopa (OR?=?1.43, CI?=?1.00 to 2.04). Results of NMA indicate that
patients with levodopa, pramipexole, ropinirole and selegiline exhibited a
significantly improved UPDRS III than those with lazabemide. To sum up, levodopa,
selegiline, ropinirole and rotigotine were recommended for PD patients as they
appeared relatively high efficacy and tolerability.