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10.1038/srep45865

http://scihub22266oqcxt.onion/10.1038/srep45865
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suck abstract from ncbi


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pmid28374775
      Sci+Rep 2017 ; 8 (ä): 45865
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  • Comparison for Efficacy and Tolerability among Ten Drugs for Treatment of Parkinson s Disease: A Network Meta-Analysis #MMPMID28374775
  • Zhuo C ; Zhu X ; Jiang R ; Ji F ; Su Z ; Xue R ; Zhou Y
  • Sci Rep 2017[Apr]; 8 (ä): 45865 PMID28374775 show ga
  • Parkinson's disease (PD) is a long term disorder affects the central nervous system and we aim to determine the relative efficacy of the current available drugs used in PD. Firstly, we performed a systematic review in current literature and eligible studies were retrieved from online databases, relevant data were extracted. Efficacy of these medications was assessed by different Unified Parkinson's Disease Rating Scales (UPDRS). Mean difference (MD) and odds ratio (OR) were produced by pairwise or network meta-analysis (NMA). Finally, we performed a cluster analysis for the included medications with respect to their surface under the cumulative ranking curve (SUCRA). Pairwise meta-analysis suggests that selegiline had a higher ranking in UPDRS II, UPDRS III and UPDRS total than bromocriptine and levodopa. Selegiline was more tolerable than bromocriptine (OR?=?0.62, CI: 0.39 to 0.98) and pramipexole was less tolerable than levodopa (OR?=?1.43, CI?=?1.00 to 2.04). Results of NMA indicate that patients with levodopa, pramipexole, ropinirole and selegiline exhibited a significantly improved UPDRS III than those with lazabemide. To sum up, levodopa, selegiline, ropinirole and rotigotine were recommended for PD patients as they appeared relatively high efficacy and tolerability.
  • |*Drug Therapy, Combination [MESH]
  • |Bromocriptine/therapeutic use [MESH]
  • |Cluster Analysis [MESH]
  • |Dopamine Agonists/*therapeutic use [MESH]
  • |Humans [MESH]
  • |Indoles/therapeutic use [MESH]
  • |Levodopa/therapeutic use [MESH]
  • |Parkinson Disease/*drug therapy/*epidemiology/pathology [MESH]
  • |Picolinic Acids/therapeutic use [MESH]
  • |Pramipexole/therapeutic use [MESH]
  • |Selegiline/therapeutic use [MESH]
  • |Tetrahydronaphthalenes/therapeutic use [MESH]


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