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10.1038/srep45819 http://scihub22266oqcxt.onion/10.1038/srep45819 C5379189!5379189 !28374855     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28374855 &cmd=llinks): Failed to open stream: HTTP request failed! 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Fibroblast growth factor 21, assisted by elevated glucose, activates paraventricular nucleus NUCB2/Nesfatin-1 neurons to produce satiety under fed states |pdf=|usr=}}{{28374855 }} gab.com Text Fibroblast growth factor 21, assisted by elevated glucose, activates paraventricular nucleus NUCB2/Nesfatin-1 neurons to produce satiety under fed states JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=28374855 #FOAvip Fibroblast growth factor 21 (FGF21), liver-derived hormone, exerts diverse metabolic effects, being considered for clinical application to treat obesity and diabetes. However, its anorexigenic effect is debatable and whether it involves the central mechanism remains unclarified. Moreover, the neuron mediating FGF21's anorexigenic effect and the systemic energy state supporting it are unclear. We explored the target neuron and fed/fasted state dependence of FGF21's anorexigenic action. Intracerebroventricular (ICV) injection of FGF21 markedly suppressed food intake in fed mice with elevated blood glucose. FGF21 induced c-Fos expression preferentially in hypothalamic paraventricular nucleus (PVN), and increased mRNA expression selectively for nucleobindin 2/nesfatin-1 (NUCB2/Nesf-1). FGF21 at elevated glucose increased [Ca(2+)](i) in PVN NUCB2/Nesf-1 neurons. FGF21 failed to suppress food intake in PVN-preferential Sim1-Nucb2-KO mice. These findings reveal that FGF21, assisted by elevated glucose, activates PVN NUCB2/Nesf-1 neurons to suppress feeding under fed states, serving as the glycemia-monitoring messenger of liver-hypothalamic network for integrative regulation of energy and glucose metabolism. Twit Text FOAVip Fibroblast growth factor 21, assisted by elevated glucose, activates paraventricular nucleus NUCB2/Nesfatin-1 neurons to produce satiety under fed states ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=28374855 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28374855 #FOAvip English Wikipedia <ref>{{Cite pmid|28374855 }}</ref> Fibroblast growth factor 21, assisted by elevated glucose, activates paraventricular nucleus NUCB2/Nesfatin-1 neurons to produce satiety under fed states #MMPMID28374855 Santoso P ; Nakata M ; Shiizaki K ; Boyang Z ; Parmila K ; Otgon-Uul Z ; Hashimoto K ; Satoh T ; Mori M ; Kuro-O M ; Yada T Sci Rep 2017[Apr]; 7 (ä): 45819 PMID28374855 show ga Fibroblast growth factor 21 (FGF21), liver-derived hormone, exerts diverse metabolic effects, being considered for clinical application to treat obesity and diabetes. However, its anorexigenic effect is debatable and whether it involves the central mechanism remains unclarified. Moreover, the neuron mediating FGF21's anorexigenic effect and the systemic energy state supporting it are unclear. We explored the target neuron and fed/fasted state dependence of FGF21's anorexigenic action. Intracerebroventricular (ICV) injection of FGF21 markedly suppressed food intake in fed mice with elevated blood glucose. FGF21 induced c-Fos expression preferentially in hypothalamic paraventricular nucleus (PVN), and increased mRNA expression selectively for nucleobindin 2/nesfatin-1 (NUCB2/Nesf-1). FGF21 at elevated glucose increased [Ca(2+)](i) in PVN NUCB2/Nesf-1 neurons. FGF21 failed to suppress food intake in PVN-preferential Sim1-Nucb2-KO mice. These findings reveal that FGF21, assisted by elevated glucose, activates PVN NUCB2/Nesf-1 neurons to suppress feeding under fed states, serving as the glycemia-monitoring messenger of liver-hypothalamic network for integrative regulation of energy and glucose metabolism. |*Blood Glucose [MESH] |Animals [MESH] |Calcium-Binding Proteins/metabolism [MESH] |DNA-Binding Proteins/metabolism [MESH] |Eating [MESH] |Fibroblast Growth Factors/*pharmacology [MESH] |Infusions, Intraventricular [MESH] |Male [MESH] |Mice [MESH] |Mice, Knockout [MESH] |Nerve Tissue Proteins/metabolism [MESH] |Neurons/drug effects [MESH] |Nucleobindins [MESH] |Paraventricular Hypothalamic Nucleus/*drug effects/metabolism [MESH] |Proto-Oncogene Proteins c-fos [MESH]Fibroblast growth factor 21, assisted by elevated glucose, activates (epmc).pdf DeepDyve Pubget Overpricing