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10.1038/ncomms14860 http://scihub22266oqcxt.onion/10.1038/ncomms14860 C5379107!5379107!28358030     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Commun 2017 ; 8 (ä): ä Nephropedia Template TP {{tp|p=28358030|t=2017. Allosteric cross-talk in chromatin can mediate drug-drug synergy |pdf=|usr=}}{{28358030}} gab.com Text Allosteric cross-talk in chromatin can mediate drug-drug synergy JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=28358030 #FOAvip Exploitation of drug?drug synergism and allostery could yield superior therapies by capitalizing on the immensely diverse, but highly specific, potential associated with the biological macromolecular landscape. Here we describe a drug?drug synergy mediated by allosteric cross-talk in chromatin, whereby the binding of one drug alters the activity of the second. We found two unrelated drugs, RAPTA-T and auranofin, that yield a synergistic activity in killing cancer cells, which coincides with a substantially greater number of chromatin adducts formed by one of the compounds when adducts from the other agent are also present. We show that this occurs through an allosteric mechanism within the nucleosome, whereby defined histone adducts of one drug promote reaction of the other drug at a distant, specific histone site. This opens up possibilities for epigenetic targeting and suggests that allosteric modulation in nucleosomes may have biological relevance and potential for therapeutic interventions. Twit Text FOAVip Allosteric cross-talk in chromatin can mediate drug-drug synergy ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=28358030 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28358030 #FOAvip English Wikipedia <ref>{{Cite pmid|28358030}}</ref> Allosteric cross-talk in chromatin can mediate drug-drug synergy #MMPMID28358030 Adhireksan Z; Palermo G; Riedel T; Ma Z; Muhammad R; Rothlisberger U; Dyson PJ; Davey CA Nat Commun 2017[]; 8 (ä): ä PMID28358030show ga Exploitation of drug?drug synergism and allostery could yield superior therapies by capitalizing on the immensely diverse, but highly specific, potential associated with the biological macromolecular landscape. Here we describe a drug?drug synergy mediated by allosteric cross-talk in chromatin, whereby the binding of one drug alters the activity of the second. We found two unrelated drugs, RAPTA-T and auranofin, that yield a synergistic activity in killing cancer cells, which coincides with a substantially greater number of chromatin adducts formed by one of the compounds when adducts from the other agent are also present. We show that this occurs through an allosteric mechanism within the nucleosome, whereby defined histone adducts of one drug promote reaction of the other drug at a distant, specific histone site. This opens up possibilities for epigenetic targeting and suggests that allosteric modulation in nucleosomes may have biological relevance and potential for therapeutic interventions. äAllosteric cross-talk in chromatin can mediate drug-drug synergy (epmc).pdf DeepDyve Pubget Overpricing