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10.1098/rstb.2015.0516 http://scihub22266oqcxt.onion/10.1098/rstb.2015.0516 C5379024!5379024!28348252     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Philos+Trans+R+Soc+Lond+B+Biol+Sci 2017 ; 372 (1720): ä Nephropedia Template TP {{tp|p=28348252|t=2017. Mechanical design in embryos: mechanical signalling, robustness and developmental defects |pdf=|usr=}}{{28348252}} gab.com Text Mechanical design in embryos: mechanical signalling, robustness and developmental defects JO: Philos Trans R Soc Lond B Biol Sci http://www.kidney.de/pget.php?&tw=1&pmid=28348252 #FOAvip Embryos are shaped by the precise application of force against the resistant structures of multicellular tissues. Forces may be generated, guided and resisted by cells, extracellular matrix, interstitial fluids, and how they are organized and bound within the tissue's architecture. In this review, we summarize our current thoughts on the multiple roles of mechanics in direct shaping, mechanical signalling and robustness of development. Genetic programmes of development interact with environmental cues to direct the composition of the early embryo and endow cells with active force production. Biophysical advances now provide experimental tools to measure mechanical resistance and collective forces during morphogenesis and are allowing integration of this field with studies of signalling and patterning during development. We focus this review on concepts that highlight this integration, and how the unique contributions of mechanical cues and gradients might be tested side by side with conventional signalling systems. We conclude with speculation on the integration of large-scale programmes of development, and how mechanical responses may ensure robust development and serve as constraints on programmes of tissue self-assembly.This article is part of the themed issue ?Systems morphodynamics: understanding the development of tissue hardware?. Twit Text FOAVip Mechanical design in embryos: mechanical signalling, robustness and developmental defects ????Philos Trans R Soc Lond B Biol Sci http://www.kidney.de/pget.php?&tw=1&pmid=28348252 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28348252 #FOAvip English Wikipedia <ref>{{Cite pmid|28348252}}</ref> Mechanical design in embryos: mechanical signalling, robustness and developmental defects #MMPMID28348252 Davidson LA Philos Trans R Soc Lond B Biol Sci 2017[May]; 372 (1720): ä PMID28348252show ga Embryos are shaped by the precise application of force against the resistant structures of multicellular tissues. Forces may be generated, guided and resisted by cells, extracellular matrix, interstitial fluids, and how they are organized and bound within the tissue's architecture. In this review, we summarize our current thoughts on the multiple roles of mechanics in direct shaping, mechanical signalling and robustness of development. Genetic programmes of development interact with environmental cues to direct the composition of the early embryo and endow cells with active force production. Biophysical advances now provide experimental tools to measure mechanical resistance and collective forces during morphogenesis and are allowing integration of this field with studies of signalling and patterning during development. We focus this review on concepts that highlight this integration, and how the unique contributions of mechanical cues and gradients might be tested side by side with conventional signalling systems. We conclude with speculation on the integration of large-scale programmes of development, and how mechanical responses may ensure robust development and serve as constraints on programmes of tissue self-assembly.This article is part of the themed issue ?Systems morphodynamics: understanding the development of tissue hardware?. äMechanical design in embryos: mechanical signalling, robustness and de(epmc).pdf DeepDyve Pubget Overpricing