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10.1016/j.celrep.2017.02.068 http://scihub22266oqcxt.onion/10.1016/j.celrep.2017.02.068 C5379009!5379009 !28329678     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28329678 &cmd=llinks): Failed to open stream: HTTP request failed! 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Human RAD52 Captures and Holds DNA Strands, Increases DNA Flexibility, and Prevents Melting of Duplex DNA: Implications for DNA Recombination |pdf=|usr=}}{{28329678 }} gab.com Text Human RAD52 Captures and Holds DNA Strands, Increases DNA Flexibility, and Prevents Melting of Duplex DNA: Implications for DNA Recombination JO: Cell Rep http://www.kidney.de/pget.php?&tw=1&pmid=28329678 #FOAvip Human RAD52 promotes annealing of complementary single-stranded DNA (ssDNA). In-depth knowledge of RAD52-DNA interaction is required to understand how its activity is integrated in DNA repair processes. Here, we visualize individual fluorescent RAD52 complexes interacting with single DNA molecules. The interaction with ssDNA is rapid, static, and tight, where ssDNA appears to wrap around RAD52 complexes that promote intra-molecular bridging. With double-stranded DNA (dsDNA), interaction is slower, weaker, and often diffusive. Interestingly, force spectroscopy experiments show that RAD52 alters the mechanics dsDNA by enhancing DNA flexibility and increasing DNA contour length, suggesting intercalation. RAD52 binding changes the nature of the overstretching transition of dsDNA and prevents DNA melting, which is advantageous for strand clamping during or after annealing. DNA-bound RAD52 is efficient at capturing ssDNA in trans. Together, these effects may help key steps in DNA repair, such as second-end capture during homologous recombination or strand annealing during RAD51-independent recombination reactions. Twit Text FOAVip Human RAD52 Captures and Holds DNA Strands, Increases DNA Flexibility, and Prevents Melting of Duplex DNA: Implications for DNA Recombination ????Cell Rep http://www.kidney.de/pget.php?&tw=1&pmid=28329678 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28329678 #FOAvip English Wikipedia <ref>{{Cite pmid|28329678 }}</ref> Human RAD52 Captures and Holds DNA Strands, Increases DNA Flexibility, and Prevents Melting of Duplex DNA: Implications for DNA Recombination #MMPMID28329678 Brouwer I ; Zhang H ; Candelli A ; Normanno D ; Peterman EJG ; Wuite GJL ; Modesti M Cell Rep 2017[Mar]; 18 (12 ): 2845-2853 PMID28329678 show ga Human RAD52 promotes annealing of complementary single-stranded DNA (ssDNA). In-depth knowledge of RAD52-DNA interaction is required to understand how its activity is integrated in DNA repair processes. Here, we visualize individual fluorescent RAD52 complexes interacting with single DNA molecules. The interaction with ssDNA is rapid, static, and tight, where ssDNA appears to wrap around RAD52 complexes that promote intra-molecular bridging. With double-stranded DNA (dsDNA), interaction is slower, weaker, and often diffusive. Interestingly, force spectroscopy experiments show that RAD52 alters the mechanics dsDNA by enhancing DNA flexibility and increasing DNA contour length, suggesting intercalation. RAD52 binding changes the nature of the overstretching transition of dsDNA and prevents DNA melting, which is advantageous for strand clamping during or after annealing. DNA-bound RAD52 is efficient at capturing ssDNA in trans. Together, these effects may help key steps in DNA repair, such as second-end capture during homologous recombination or strand annealing during RAD51-independent recombination reactions. |*Nucleic Acid Denaturation [MESH] |*Recombination, Genetic [MESH] |DNA, Single-Stranded/metabolism [MESH] |DNA/*metabolism [MESH] |Diffusion [MESH] |Green Fluorescent Proteins/metabolism [MESH] |Humans [MESH] |Protein Binding [MESH]Human RAD52 Captures and Holds DNA Strands, Increases DNA Flexibility,(epmc).pdf DeepDyve Pubget Overpricing