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10.1007/s00018-016-2418-4 http://scihub22266oqcxt.onion/10.1007/s00018-016-2418-4 C5378756!5378756!27942748     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell+Mol+Life+Sci 2017 ; 74 (9): 1605-24 Nephropedia Template TP {{tp|p=27942748|t=2017. Complement factor H in host defense and immune evasion |pdf=|usr=}}{{27942748}} gab.com Text Complement factor H in host defense and immune evasion JO: Cell Mol Life Sci http://www.kidney.de/pget.php?&tw=1&pmid=27942748 #FOAvip Complement is the major humoral component of the innate immune system. It recognizes pathogen- and damage-associated molecular patterns, and initiates the immune response in coordination with innate and adaptive immunity. When activated, the complement system unleashes powerful cytotoxic and inflammatory mechanisms, and thus its tight control is crucial to prevent damage to host tissues and allow restoration of immune homeostasis. Factor H is the major soluble inhibitor of complement, where its binding to self markers (i.e., particular glycan structures) prevents complement activation and amplification on host surfaces. Not surprisingly, mutations and polymorphisms that affect recognition of self by factor H are associated with diseases of complement dysregulation, such as age-related macular degeneration and atypical haemolytic uremic syndrome. In addition, pathogens (i.e., non-self) and cancer cells (i.e., altered-self) can hijack factor H to evade the immune response. Here we review recent (and not so recent) literature on the structure and function of factor H, including the emerging roles of this protein in the pathophysiology of infectious diseases and cancer. Twit Text FOAVip Complement factor H in host defense and immune evasion ????Cell Mol Life Sci http://www.kidney.de/pget.php?&tw=1&pmid=27942748 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27942748 #FOAvip English Wikipedia <ref>{{Cite pmid|27942748}}</ref> Complement factor H in host defense and immune evasion #MMPMID27942748 Parente R; Clark SJ; Inforzato A; Day AJ Cell Mol Life Sci 2017[]; 74 (9): 1605-24 PMID27942748show ga Complement is the major humoral component of the innate immune system. It recognizes pathogen- and damage-associated molecular patterns, and initiates the immune response in coordination with innate and adaptive immunity. When activated, the complement system unleashes powerful cytotoxic and inflammatory mechanisms, and thus its tight control is crucial to prevent damage to host tissues and allow restoration of immune homeostasis. Factor H is the major soluble inhibitor of complement, where its binding to self markers (i.e., particular glycan structures) prevents complement activation and amplification on host surfaces. Not surprisingly, mutations and polymorphisms that affect recognition of self by factor H are associated with diseases of complement dysregulation, such as age-related macular degeneration and atypical haemolytic uremic syndrome. In addition, pathogens (i.e., non-self) and cancer cells (i.e., altered-self) can hijack factor H to evade the immune response. Here we review recent (and not so recent) literature on the structure and function of factor H, including the emerging roles of this protein in the pathophysiology of infectious diseases and cancer. äComplement factor H in host defense and immune evasion (epmc).pdf DeepDyve Pubget Overpricing