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10.3389/fonc.2017.00049 http://scihub22266oqcxt.onion/10.3389/fonc.2017.00049 C5378717!5378717!28421159     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Front+Oncol 2017 ; 7 (ä): ä Nephropedia Template TP {{tp|p=28421159|t=2017. Mammalian SWI/SNF Enzymes and the Epigenetics of Tumor Cell Metabolic Reprogramming |pdf=|usr=}}{{28421159}} gab.com Text Mammalian SWI/SNF Enzymes and the Epigenetics of Tumor Cell Metabolic Reprogramming JO: Front Oncol http://www.kidney.de/pget.php?&tw=1&pmid=28421159 #FOAvip Tumor cells reprogram their metabolism to survive and grow in a challenging microenvironment. Some of this reprogramming is performed by epigenetic mechanisms. Epigenetics is in turn affected by metabolism; chromatin modifying enzymes are dependent on substrates that are also key metabolic intermediates. We have shown that the chromatin remodeling enzyme Brahma-related gene 1 (BRG1), an epigenetic regulator, is necessary for rapid breast cancer cell proliferation. The mechanism for this requirement is the BRG1-dependent transcription of key lipogenic enzymes and regulators. Reduction in lipid synthesis lowers proliferation rates, which can be restored by palmitate supplementation. This work has established BRG1 as an attractive target for breast cancer therapy. Unlike genetic alterations, epigenetic mechanisms are reversible, promising gentler therapies without permanent off-target effects at distant sites. Twit Text FOAVip Mammalian SWI/SNF Enzymes and the Epigenetics of Tumor Cell Metabolic Reprogramming ????Front Oncol http://www.kidney.de/pget.php?&tw=1&pmid=28421159 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28421159 #FOAvip English Wikipedia <ref>{{Cite pmid|28421159}}</ref> Mammalian SWI/SNF Enzymes and the Epigenetics of Tumor Cell Metabolic Reprogramming #MMPMID28421159 Nickerson JA; Wu Q; Imbalzano AN Front Oncol 2017[]; 7 (ä): ä PMID28421159show ga Tumor cells reprogram their metabolism to survive and grow in a challenging microenvironment. Some of this reprogramming is performed by epigenetic mechanisms. Epigenetics is in turn affected by metabolism; chromatin modifying enzymes are dependent on substrates that are also key metabolic intermediates. We have shown that the chromatin remodeling enzyme Brahma-related gene 1 (BRG1), an epigenetic regulator, is necessary for rapid breast cancer cell proliferation. The mechanism for this requirement is the BRG1-dependent transcription of key lipogenic enzymes and regulators. Reduction in lipid synthesis lowers proliferation rates, which can be restored by palmitate supplementation. This work has established BRG1 as an attractive target for breast cancer therapy. Unlike genetic alterations, epigenetic mechanisms are reversible, promising gentler therapies without permanent off-target effects at distant sites. äMammalian SWI/SNF Enzymes and the Epigenetics of Tumor Cell Metabolic (epmc).pdf DeepDyve Pubget Overpricing