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2017 ; 8
(ä): 542
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Cranberry Juice and Combinations of Its Organic Acids Are Effective against
Experimental Urinary Tract Infection
#MMPMID28421045
Jensen HD
; Struve C
; Christensen SB
; Krogfelt KA
Front Microbiol
2017[]; 8
(ä): 542
PMID28421045
show ga
The antibacterial effect of cranberry juice and the organic acids therein on
infection by uropathogenic Escherichia coli was studied in an experimental mouse
model of urinary tract infection (UTI). Reduced bacterial counts were found in
the bladder (P < 0.01) of mice drinking fresh cranberry juice. Commercially
available cranberry juice cocktail also significantly reduced (P < 0.01)
bacterial populations in the bladder, as did the hydrophilic fraction of
cranberry juice (P < 0.05). Quinic, malic, shikimic, and citric acid, the
preponderant organic acids in cranberry juice, were tested in combination and
individually. The four organic acids also decreased bacterial levels in the
bladder when administered together (P < 0.001), and so did the combination of
malic plus citric acid (P < 0.01) and malic plus quinic acid (P < 0.05). The
other tested combinations of the organic acids, and the acids administered
singly, did not have any effect in the UTI model. Apparently, the antibacterial
effect of the organic acids from cranberry juice on UTI can be obtained by
administering a combination of malic acid and either citric or quinic acid. This
study show for the first time that cranberry juice reduce E. coli colonization of
the bladder in an experimental mouse model of urinary tract infection and that
the organic acids are active agents.