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10.1016/j.it.2017.01.002 http://scihub22266oqcxt.onion/10.1016/j.it.2017.01.002 C5378645!5378645!28233639     free     free     free       Trends+Immunol 2017 ; 38 (4): 298-305 Nephropedia Template TP {{tp|p=28233639|t=2017. MYC: Master Regulator of Immune Privilege |pdf=|usr=}}{{28233639}} gab.com Text MYC: Master Regulator of Immune Privilege JO: Trends Immunol http://www.kidney.de/pget.php?&tw=1&pmid=28233639 #FOAvip Cancers are often initiated by genetic events that activate proto-oncogenes or inactivate tumor suppressor genes. These events are also critical for sustained tumor cell proliferation and survival, a phenomenon described as oncogene addiction. In addition to this cell intrinsic role, recent evidence indicates that oncogenes also directly regulate immune responses, leading to immunosuppression. Expression of many oncogenes, or loss of tumor suppressors, indeed induces the expression of immune checkpoints including PD-L1, which regulate the immune response. Here, we discuss how oncogenes, and in particular MYC, suppress immune surveillance and how oncogene-targeted therapies may restore the immune response against tumors. Twit Text FOAVip MYC: Master Regulator of Immune Privilege ????Trends Immunol http://www.kidney.de/pget.php?&tw=1&pmid=28233639 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28233639 #FOAvip English Wikipedia <ref>{{Cite pmid|28233639}}</ref> MYC: Master Regulator of Immune Privilege #MMPMID28233639 Casey SC; Baylot V; Felsher DW Trends Immunol 2017[Apr]; 38 (4): 298-305 PMID28233639show ga Cancers are often initiated by genetic events that activate proto-oncogenes or inactivate tumor suppressor genes. These events are also critical for sustained tumor cell proliferation and survival, a phenomenon described as oncogene addiction. In addition to this cell intrinsic role, recent evidence indicates that oncogenes also directly regulate immune responses, leading to immunosuppression. Expression of many oncogenes, or loss of tumor suppressors, indeed induces the expression of immune checkpoints including PD-L1, which regulate the immune response. Here, we discuss how oncogenes, and in particular MYC, suppress immune surveillance and how oncogene-targeted therapies may restore the immune response against tumors. äMYC: Master Regulator of Immune Privilege (epmc).pdf DeepDyve Pubget Overpricing