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10.1111/febs.13961 http://scihub22266oqcxt.onion/10.1111/febs.13961 C5378628!5378628!27863012     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       FEBS+J 2017 ; 284 (7): 1021-39 Nephropedia Template TP {{tp|p=27863012|t=2017. Maxed out macs: physiologic cell clearance as a function of macrophage phagocytic capacity |pdf=|usr=}}{{27863012}} gab.com Text Maxed out macs: physiologic cell clearance as a function of macrophage phagocytic capacity JO: FEBS J http://www.kidney.de/pget.php?&tw=1&pmid=27863012 #FOAvip The phagocytic clearance of host cells is important for eliminating dying cells and for the therapeutic clearance of antibody-targeted cells. As ubiquitous, motile and highly phagocytic immune cells, macrophages are principal players in the phagocytic removal of host cells throughout the body. In recent years great strides have been made in identifying the molecular mechanisms that control the recognition and phagocytosis of cells by macrophages. However, much less is known about the physical and metabolic constraints that govern the amount of cellular material macrophages can ingest and how these limitations affect the overall efficiency of host cell clearance in health and disease. In this review we will discuss, in the contexts of apoptotic cells and antibody-targeted malignant cells, how physical and metabolic factors associated with the internalization of host cells are relayed to the phagocytic machinery and how these signals can impact the overall efficiency of cell clearance. We also discuss how this information can be leveraged to increase cell clearance for beneficial therapeutic outcomes. Twit Text FOAVip Maxed out macs: physiologic cell clearance as a function of macrophage phagocytic capacity ????FEBS J http://www.kidney.de/pget.php?&tw=1&pmid=27863012 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27863012 #FOAvip English Wikipedia <ref>{{Cite pmid|27863012}}</ref> Maxed out macs: physiologic cell clearance as a function of macrophage phagocytic capacity #MMPMID27863012 Zent CS; Elliott MR FEBS J 2017[Apr]; 284 (7): 1021-39 PMID27863012show ga The phagocytic clearance of host cells is important for eliminating dying cells and for the therapeutic clearance of antibody-targeted cells. As ubiquitous, motile and highly phagocytic immune cells, macrophages are principal players in the phagocytic removal of host cells throughout the body. In recent years great strides have been made in identifying the molecular mechanisms that control the recognition and phagocytosis of cells by macrophages. However, much less is known about the physical and metabolic constraints that govern the amount of cellular material macrophages can ingest and how these limitations affect the overall efficiency of host cell clearance in health and disease. In this review we will discuss, in the contexts of apoptotic cells and antibody-targeted malignant cells, how physical and metabolic factors associated with the internalization of host cells are relayed to the phagocytic machinery and how these signals can impact the overall efficiency of cell clearance. We also discuss how this information can be leveraged to increase cell clearance for beneficial therapeutic outcomes. äMaxed out macs: physiologic cell clearance as a function of macrophage(epmc).pdf DeepDyve Pubget Overpricing