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10.1111/jth.12253 http://scihub22266oqcxt.onion/10.1111/jth.12253 C5378490!5378490!23809110     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Thromb+Haemost 2013 ; 11 (Suppl 1): 46-66 Nephropedia Template TP {{tp|p=23809110|t=2013. Evolutionary origins of the blood vascular system and endothelium |pdf=|usr=}}{{23809110}} gab.com Text Evolutionary origins of the blood vascular system and endothelium JO: J Thromb Haemost http://www.kidney.de/pget.php?&tw=1&pmid=23809110 #FOAvip Every biological trait requires both a proximate and evolutionary explanation. The field of vascular biology is focused primarily on proximate mechanisms in health and disease. Comparatively little attention has been given to the evolutionary basis of the cardiovascular system. Here, we employ a comparative approach to review the phylogenetic history of the blood vascular system and endothelium. In addition to drawing on the published literature, we provide primary ultrastructural data related to the lobster, earthworm, amphioxus and hagfish. Existing evidence suggests that the blood vascular system first appeared in an ancestor of the triploblasts over 600 million years ago, as a means to overcome the time-distance constraints of diffusion. The endothelium evolved in an ancestral vertebrate some 540?510 million years ago to optimize flow dynamics and barrier function, and/or to localize immune and coagulation functions. Finally, we emphasize that endothelial heterogeneity evolved as a core feature of the endothelium from the outset, reflecting its role in meeting the diverse needs of body tissues. Twit Text FOAVip Evolutionary origins of the blood vascular system and endothelium ????J Thromb Haemost http://www.kidney.de/pget.php?&tw=1&pmid=23809110 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=23809110 #FOAvip English Wikipedia <ref>{{Cite pmid|23809110}}</ref> Evolutionary origins of the blood vascular system and endothelium #MMPMID23809110 Monahan-Earley R; Dvorak AM; Aird WC J Thromb Haemost 2013[Jun]; 11 (Suppl 1): 46-66 PMID23809110show ga Every biological trait requires both a proximate and evolutionary explanation. The field of vascular biology is focused primarily on proximate mechanisms in health and disease. Comparatively little attention has been given to the evolutionary basis of the cardiovascular system. Here, we employ a comparative approach to review the phylogenetic history of the blood vascular system and endothelium. In addition to drawing on the published literature, we provide primary ultrastructural data related to the lobster, earthworm, amphioxus and hagfish. Existing evidence suggests that the blood vascular system first appeared in an ancestor of the triploblasts over 600 million years ago, as a means to overcome the time-distance constraints of diffusion. The endothelium evolved in an ancestral vertebrate some 540?510 million years ago to optimize flow dynamics and barrier function, and/or to localize immune and coagulation functions. Finally, we emphasize that endothelial heterogeneity evolved as a core feature of the endothelium from the outset, reflecting its role in meeting the diverse needs of body tissues. äEvolutionary origins of the blood vascular system and endothelium (epmc).pdf DeepDyve Pubget Overpricing