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10.2147/DDDT.S129305 http://scihub22266oqcxt.onion/10.2147/DDDT.S129305 C5378468!5378468!28405157     free     free     free Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Drug+Des+Devel+Ther 2017 ; 11 (ä): 969-83 Nephropedia Template TP {{tp|p=28405157|t=2017. Decitabine reverses TGF-?1-induced epithelial?mesenchymal transition in non-small-cell lung cancer by regulating miR-200/ZEB axis |pdf=|usr=}}{{28405157}} gab.com Text Decitabine reverses TGF- 1-induced epithelial mesenchymal transition in non-small-cell lung cancer by regulating miR-200/ZEB axis JO: Drug Des Devel Ther http://www.kidney.de/pget.php?&tw=1&pmid=28405157 #FOAvip Objective: Epithelial?mesenchymal transition (EMT) is a crucial driver of tumor progression. Tumor growth factor-beta 1 (TGF-?1) is an important factor in EMT induction in tumorigenesis. The targeting of EMT may, therefore, represent a promising approach in anticancer treatment. Methods: In this study, we determined the effect of decitabine, a DNA methyltransferase inhibitor, on TGF-?1-induced EMT in non-small-cell lung cancer (NSCLC) PC9 and A549 cells. We also assessed the involvement of the miR-200/ZEB axis. Results: Decitabine reversed TGF-?1-induced EMT in PC9 cells, but not in A549 cells. This phenomenon was associated with epigenetic changes in the miR-200 family, which regulated EMT by altering the expression of ZEB1 and ZEB2. TGF-?1 induced aberrant methylation in miR-200 promoters, leading to EMT in PC9 cells. Decitabine attenuated this effect and inhibited tumor cell migration in vitro and in vivo. In A549 cells, however, neither TGF-?1 nor decitabine exhibited an effect on miR-200 promoter methylation. Conclusion: Our findings suggest that epigenetic regulation of the miR-200/ZEB axis is responsible for EMT induction by TGF-?1 in PC9 cells. Decitabine inhibits EMT in NSCLC cell PC9 through its epigenetic-based therapeutic activity. Twit Text FOAVip Decitabine reverses TGF- 1-induced epithelial mesenchymal transition in non-small-cell lung cancer by regulating miR-200/ZEB axis ????Drug Des Devel Ther http://www.kidney.de/pget.php?&tw=1&pmid=28405157 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28405157 #FOAvip English Wikipedia <ref>{{Cite pmid|28405157}}</ref> Decitabine reverses TGF-?1-induced epithelial?mesenchymal transition in non-small-cell lung cancer by regulating miR-200/ZEB axis #MMPMID28405157 Zhang N; Liu Y; Wang Y; Zhao M; Tu L; Luo F Drug Des Devel Ther 2017[]; 11 (ä): 969-83 PMID28405157show ga Objective: Epithelial?mesenchymal transition (EMT) is a crucial driver of tumor progression. Tumor growth factor-beta 1 (TGF-?1) is an important factor in EMT induction in tumorigenesis. The targeting of EMT may, therefore, represent a promising approach in anticancer treatment. Methods: In this study, we determined the effect of decitabine, a DNA methyltransferase inhibitor, on TGF-?1-induced EMT in non-small-cell lung cancer (NSCLC) PC9 and A549 cells. We also assessed the involvement of the miR-200/ZEB axis. Results: Decitabine reversed TGF-?1-induced EMT in PC9 cells, but not in A549 cells. This phenomenon was associated with epigenetic changes in the miR-200 family, which regulated EMT by altering the expression of ZEB1 and ZEB2. TGF-?1 induced aberrant methylation in miR-200 promoters, leading to EMT in PC9 cells. Decitabine attenuated this effect and inhibited tumor cell migration in vitro and in vivo. In A549 cells, however, neither TGF-?1 nor decitabine exhibited an effect on miR-200 promoter methylation. Conclusion: Our findings suggest that epigenetic regulation of the miR-200/ZEB axis is responsible for EMT induction by TGF-?1 in PC9 cells. Decitabine inhibits EMT in NSCLC cell PC9 through its epigenetic-based therapeutic activity. äDecitabine reverses TGF-?1-induced epithelial?mesenchymal transition i(epmc).pdf DeepDyve Pubget Overpricing