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10.2147/DDDT.S129305 http://scihub22266oqcxt.onion/10.2147/DDDT.S129305 C5378468!5378468 !28405157     free     free     free Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28405157 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Drug+Des+Devel+Ther 2017 ; 11 (ä): 969-983 Nephropedia Template TP {{tp|p=28405157 |t=2017. Decitabine reverses TGF-?1-induced epithelial-mesenchymal transition in non-small-cell lung cancer by regulating miR-200/ZEB axis |pdf=|usr=}}{{28405157 }} gab.com Text Decitabine reverses TGF- 1-induced epithelial-mesenchymal transition in non-small-cell lung cancer by regulating miR-200/ZEB axis JO: Drug Des Devel Ther http://www.kidney.de/pget.php?&tw=1&pmid=28405157 #FOAvip OBJECTIVE: Epithelial-mesenchymal transition (EMT) is a crucial driver of tumor progression. Tumor growth factor-beta 1 (TGF-?1) is an important factor in EMT induction in tumorigenesis. The targeting of EMT may, therefore, represent a promising approach in anticancer treatment. METHODS: In this study, we determined the effect of decitabine, a DNA methyltransferase inhibitor, on TGF-?1-induced EMT in non-small-cell lung cancer (NSCLC) PC9 and A549 cells. We also assessed the involvement of the miR-200/ZEB axis. RESULTS: Decitabine reversed TGF-?1-induced EMT in PC9 cells, but not in A549 cells. This phenomenon was associated with epigenetic changes in the miR-200 family, which regulated EMT by altering the expression of ZEB1 and ZEB2. TGF-?1 induced aberrant methylation in miR-200 promoters, leading to EMT in PC9 cells. Decitabine attenuated this effect and inhibited tumor cell migration in vitro and in vivo. In A549 cells, however, neither TGF-?1 nor decitabine exhibited an effect on miR-200 promoter methylation. CONCLUSION: Our findings suggest that epigenetic regulation of the miR-200/ZEB axis is responsible for EMT induction by TGF-?1 in PC9 cells. Decitabine inhibits EMT in NSCLC cell PC9 through its epigenetic-based therapeutic activity. Twit Text FOAVip Decitabine reverses TGF- 1-induced epithelial-mesenchymal transition in non-small-cell lung cancer by regulating miR-200/ZEB axis ????Drug Des Devel Ther http://www.kidney.de/pget.php?&tw=1&pmid=28405157 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28405157 #FOAvip English Wikipedia <ref>{{Cite pmid|28405157 }}</ref> Decitabine reverses TGF-?1-induced epithelial-mesenchymal transition in non-small-cell lung cancer by regulating miR-200/ZEB axis #MMPMID28405157 Zhang N ; Liu Y ; Wang Y ; Zhao M ; Tu L ; Luo F Drug Des Devel Ther 2017[]; 11 (ä): 969-983 PMID28405157 show ga OBJECTIVE: Epithelial-mesenchymal transition (EMT) is a crucial driver of tumor progression. Tumor growth factor-beta 1 (TGF-?1) is an important factor in EMT induction in tumorigenesis. The targeting of EMT may, therefore, represent a promising approach in anticancer treatment. METHODS: In this study, we determined the effect of decitabine, a DNA methyltransferase inhibitor, on TGF-?1-induced EMT in non-small-cell lung cancer (NSCLC) PC9 and A549 cells. We also assessed the involvement of the miR-200/ZEB axis. RESULTS: Decitabine reversed TGF-?1-induced EMT in PC9 cells, but not in A549 cells. This phenomenon was associated with epigenetic changes in the miR-200 family, which regulated EMT by altering the expression of ZEB1 and ZEB2. TGF-?1 induced aberrant methylation in miR-200 promoters, leading to EMT in PC9 cells. Decitabine attenuated this effect and inhibited tumor cell migration in vitro and in vivo. In A549 cells, however, neither TGF-?1 nor decitabine exhibited an effect on miR-200 promoter methylation. CONCLUSION: Our findings suggest that epigenetic regulation of the miR-200/ZEB axis is responsible for EMT induction by TGF-?1 in PC9 cells. Decitabine inhibits EMT in NSCLC cell PC9 through its epigenetic-based therapeutic activity. |Animals [MESH] |Antineoplastic Agents/administration & dosage/*pharmacology/therapeutic use [MESH] |Azacitidine/administration & dosage/*analogs & derivatives/pharmacology/therapeutic use [MESH] |Carcinoma, Non-Small-Cell Lung/*drug therapy/metabolism/pathology [MESH] |Cell Survival/drug effects [MESH] |Decitabine [MESH] |Epithelial-Mesenchymal Transition/*drug effects [MESH] |Female [MESH] |Humans [MESH] |Lung Neoplasms/*drug therapy/metabolism/pathology [MESH] |Mice [MESH] |Mice, Inbred NOD [MESH] |Mice, SCID [MESH] |MicroRNAs/genetics/metabolism [MESH] |Neoplasms, Experimental/drug therapy/metabolism/pathology [MESH] |Transforming Growth Factor beta1/*antagonists & inhibitors/metabolism [MESH] |Tumor Cells, Cultured [MESH]Decitabine reverses TGF-?1-induced epithelial-mesenchymal transition i(epmc).pdf DeepDyve Pubget Overpricing