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10.1371/journal.pone.0174633 http://scihub22266oqcxt.onion/10.1371/journal.pone.0174633 C5378338!5378338 !28369143     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28369143 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215       PLoS+One 2017 ; 12 (4 ): e0174633 Nephropedia Template TP {{tp|p=28369143 |t=2017. Yap/Taz transcriptional activity is essential for vascular regression via Ctgf expression and actin polymerization |pdf=|usr=}}{{28369143 }} gab.com Text Yap/Taz transcriptional activity is essential for vascular regression via Ctgf expression and actin polymerization JO: PLoS One http://www.kidney.de/pget.php?&tw=1&pmid=28369143 #FOAvip Vascular regression is essential to remove redundant vessels during the formation of an efficient vascular network that can transport oxygen and nutrient to every corner of the body. However, no mechanism is known to explain how major blood vessels regress during development. Here we use the dorsal part of the caudal vein plexus (dCVP) in Zebrafish to investigate the mechanism of regression and discover a new role of Yap/Taz in vascular regression. During regression, Yap/Taz is activated by blood circulation in the endothelial cells. This leads to induction of Ctgf and actin polymerization. Interference with Yap/Taz activation decreased Ctgf production, which decreased actin polymerization and vascular regression. These results implicate a novel role of Yap/Taz in vascular regression. Twit Text FOAVip Yap/Taz transcriptional activity is essential for vascular regression via Ctgf expression and actin polymerization ????PLoS One http://www.kidney.de/pget.php?&tw=1&pmid=28369143 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28369143 #FOAvip English Wikipedia <ref>{{Cite pmid|28369143 }}</ref> Yap/Taz transcriptional activity is essential for vascular regression via Ctgf expression and actin polymerization #MMPMID28369143 Nagasawa-Masuda A ; Terai K PLoS One 2017[]; 12 (4 ): e0174633 PMID28369143 show ga Vascular regression is essential to remove redundant vessels during the formation of an efficient vascular network that can transport oxygen and nutrient to every corner of the body. However, no mechanism is known to explain how major blood vessels regress during development. Here we use the dorsal part of the caudal vein plexus (dCVP) in Zebrafish to investigate the mechanism of regression and discover a new role of Yap/Taz in vascular regression. During regression, Yap/Taz is activated by blood circulation in the endothelial cells. This leads to induction of Ctgf and actin polymerization. Interference with Yap/Taz activation decreased Ctgf production, which decreased actin polymerization and vascular regression. These results implicate a novel role of Yap/Taz in vascular regression. |Actins/*metabolism [MESH] |Acyltransferases [MESH] |Animals [MESH] |Animals, Genetically Modified [MESH] |Cell Line [MESH] |Connective Tissue Growth Factor/*biosynthesis [MESH] |HEK293 Cells [MESH] |Human Umbilical Vein Endothelial Cells/metabolism [MESH] |Humans [MESH] |In Situ Hybridization [MESH] |Morpholinos/genetics [MESH] |Neovascularization, Physiologic [MESH] |Trans-Activators/genetics/*metabolism [MESH] |Transcription Factors/genetics/*metabolism [MESH] |Transcriptional Activation/genetics [MESH] |YAP-Signaling Proteins [MESH] |Zebrafish Proteins/genetics/*metabolism [MESH]Yap/Taz transcriptional activity is essential for vascular regression (epmc).pdf DeepDyve Pubget Overpricing