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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Cancer+Sci
2017 ; 108
(3
): 290-295
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Possible functions of CD169-positive sinus macrophages in lymph nodes in
anti-tumor immune responses
#MMPMID28002629
Komohara Y
; Ohnishi K
; Takeya M
Cancer Sci
2017[Mar]; 108
(3
): 290-295
PMID28002629
show ga
The lymph node (LN) is an important immune system in which a number of
antigen-presenting cells are present that induce rapid immune responses to
foreign antigens. While a great number of macrophages exist in lymph nodes,
recent studies using animal models have shown that lymph node sinus macrophages
are associated with the induction of anti-tumor immunity, playing a significant
role in host immune responses against tumor cells. In colorectal tumor, malignant
melanoma, and endometrial tumor, it was shown that a high density of
CD169-positive macrophages in the LN sinus was a predictive factor for better
clinical prognosis. The observations that the density of CD169-positive
macrophages in the LN sinus was positively associated with the density of
infiltrating T or NK cells in tumor tissues, indicates the significance of
CD169-positive macrophages in anti-tumor immune reactions of tumor patients.
Moreover, antigen delivery targeting LN macrophages is also considered to be
promising approach for vaccination. In this article, we have summarized the
significance of CD169-positive LN macrophages in anti-tumor immunity.