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10.1111/cas.13153 http://scihub22266oqcxt.onion/10.1111/cas.13153 C5378274!5378274!28032931     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cancer+Sci 2017 ; 108 (3): 380-9 Nephropedia Template TP {{tp|p=28032931|t=2017. FKBP51 regulates cell motility and invasion via RhoA signaling |pdf=|usr=}}{{28032931}} gab.com Text FKBP51 regulates cell motility and invasion via RhoA signaling JO: Cancer Sci http://www.kidney.de/pget.php?&tw=1&pmid=28032931 #FOAvip FK506 binding protein 51 (FKBP51), a member of the immunophilin family, is involved in multiple signaling pathways, tumorigenesis, and chemoresistance. FKBP51 expression correlates with metastatic potential in melanoma and prostate cancer. However, the functions of FKBP51, particularly involving the regulation of cell motility and invasion, are not fully understood. We discovered two novel interacting partner proteins of FKBP51, i.e., deleted in liver cancer 1 (DLC1) and deleted in liver cancer 2 (DLC2), using immunoprecipitation and mass spectrometry. DLC1 and DLC2 are Rho GTPase?activating proteins that are frequently downregulated in various cancers. Next, we demonstrated that overexpression of FKBP51 enhances cell motility and invasion of U2OS cells via upregulation of RhoA activity and enhanced Rho?ROCK signaling. Moreover, FKBP51?depleted cells displayed a cortical distribution of actin filaments and decreased cell motility and invasion. Consistent with this phenotype, FKBP51 depletion caused a downregulation of RhoA activity. Considered together, our results demonstrate that FKBP51 positively controls cell motility by promoting RhoA and ROCK activation; thus, we have revealed a novel role for FKBP51 in cytoskeletal rearrangement and cell migration and invasion. Twit Text FOAVip FKBP51 regulates cell motility and invasion via RhoA signaling ????Cancer Sci http://www.kidney.de/pget.php?&tw=1&pmid=28032931 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28032931 #FOAvip English Wikipedia <ref>{{Cite pmid|28032931}}</ref> FKBP51 regulates cell motility and invasion via RhoA signaling #MMPMID28032931 Takaoka M; Ito S; Miki Y; Nakanishi A Cancer Sci 2017[Mar]; 108 (3): 380-9 PMID28032931show ga FK506 binding protein 51 (FKBP51), a member of the immunophilin family, is involved in multiple signaling pathways, tumorigenesis, and chemoresistance. FKBP51 expression correlates with metastatic potential in melanoma and prostate cancer. However, the functions of FKBP51, particularly involving the regulation of cell motility and invasion, are not fully understood. We discovered two novel interacting partner proteins of FKBP51, i.e., deleted in liver cancer 1 (DLC1) and deleted in liver cancer 2 (DLC2), using immunoprecipitation and mass spectrometry. DLC1 and DLC2 are Rho GTPase?activating proteins that are frequently downregulated in various cancers. Next, we demonstrated that overexpression of FKBP51 enhances cell motility and invasion of U2OS cells via upregulation of RhoA activity and enhanced Rho?ROCK signaling. Moreover, FKBP51?depleted cells displayed a cortical distribution of actin filaments and decreased cell motility and invasion. Consistent with this phenotype, FKBP51 depletion caused a downregulation of RhoA activity. Considered together, our results demonstrate that FKBP51 positively controls cell motility by promoting RhoA and ROCK activation; thus, we have revealed a novel role for FKBP51 in cytoskeletal rearrangement and cell migration and invasion. äFKBP51 regulates cell motility and invasion via RhoA signaling (epmc).pdf DeepDyve Pubget Overpricing