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10.1111/cas.13142 http://scihub22266oqcxt.onion/10.1111/cas.13142 C5378270!5378270!28004467     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cancer+Sci 2017 ; 108 (3): 528-35 Nephropedia Template TP {{tp|p=28004467|t=2017. Podocalyxin influences malignant potential by controlling epithelial?mesenchymal transition in lung adenocarcinoma |pdf=|usr=}}{{28004467}} gab.com Text Podocalyxin influences malignant potential by controlling epithelial mesenchymal transition in lung adenocarcinoma JO: Cancer Sci http://www.kidney.de/pget.php?&tw=1&pmid=28004467 #FOAvip Epithelial?mesenchymal transition (EMT) plays an important role in the progression of lung carcinoma. Podocalyxin (PODXL), which belongs to the CD34 family and regulates cell morphology, has been linked to EMT in lung cancer, and PODXL overexpression is associated with poor prognosis in several different classes of cancers. The aim of this study was to clarify the role of PODXL overexpression in EMT in lung cancer, and to determine the prognostic value of PODXL overexpression in tumors from lung cancer patients. The morphology, EMT marker expression, and migration and invasion abilities of engineered A549 PODXL?knockdown (KD) or PODXL?overexpression (OE) lung adenocarcinoma cells were examined. PODXL expression levels were assessed by immunohistochemistry in 114 human clinical lung adenocarcinoma specimens and correlated with clinical outcomes. PODXL?KD cells were epithelial in shape, whereas PODXL?OE cells displayed mesenchymal morphology. Epithelial markers were upregulated in PODXL?KD cells and downregulated in PODXL?OE cells, whereas mesenchymal markers were downregulated in the former and upregulated in the latter. A highly selective inhibitor of phosphatidylinositol 3?kinase?Akt signaling attenuated EMT of PODXL?OE cells, while a transforming growth factor inhibitor did not, suggesting that PODXL induces EMT of lung adenocarcinoma cells via the phosphatidylinositol 3?kinase pathway. In lung adenocarcinoma clinical specimens, PODXL expression was detected in minimally invasive and invasive adenocarcinoma, but not in non?invasive adenocarcinoma. Disease free survival and cancer?specific survival were significantly worse for patients whose tumors overexpressed PODXL. PODXL overexpression induces EMT in lung adenocarcinoma and contributes to tumor progression. Twit Text FOAVip Podocalyxin influences malignant potential by controlling epithelial mesenchymal transition in lung adenocarcinoma ????Cancer Sci http://www.kidney.de/pget.php?&tw=1&pmid=28004467 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28004467 #FOAvip English Wikipedia <ref>{{Cite pmid|28004467}}</ref> Podocalyxin influences malignant potential by controlling epithelial?mesenchymal transition in lung adenocarcinoma #MMPMID28004467 Kusumoto H; Shintani Y; Kanzaki R; Kawamura T; Funaki S; Minami M; Nagatomo I; Morii E; Okumura M Cancer Sci 2017[Mar]; 108 (3): 528-35 PMID28004467show ga Epithelial?mesenchymal transition (EMT) plays an important role in the progression of lung carcinoma. Podocalyxin (PODXL), which belongs to the CD34 family and regulates cell morphology, has been linked to EMT in lung cancer, and PODXL overexpression is associated with poor prognosis in several different classes of cancers. The aim of this study was to clarify the role of PODXL overexpression in EMT in lung cancer, and to determine the prognostic value of PODXL overexpression in tumors from lung cancer patients. The morphology, EMT marker expression, and migration and invasion abilities of engineered A549 PODXL?knockdown (KD) or PODXL?overexpression (OE) lung adenocarcinoma cells were examined. PODXL expression levels were assessed by immunohistochemistry in 114 human clinical lung adenocarcinoma specimens and correlated with clinical outcomes. PODXL?KD cells were epithelial in shape, whereas PODXL?OE cells displayed mesenchymal morphology. Epithelial markers were upregulated in PODXL?KD cells and downregulated in PODXL?OE cells, whereas mesenchymal markers were downregulated in the former and upregulated in the latter. A highly selective inhibitor of phosphatidylinositol 3?kinase?Akt signaling attenuated EMT of PODXL?OE cells, while a transforming growth factor inhibitor did not, suggesting that PODXL induces EMT of lung adenocarcinoma cells via the phosphatidylinositol 3?kinase pathway. In lung adenocarcinoma clinical specimens, PODXL expression was detected in minimally invasive and invasive adenocarcinoma, but not in non?invasive adenocarcinoma. Disease free survival and cancer?specific survival were significantly worse for patients whose tumors overexpressed PODXL. PODXL overexpression induces EMT in lung adenocarcinoma and contributes to tumor progression. äPodocalyxin influences malignant potential by controlling epithelial?m(epmc).pdf DeepDyve Pubget Overpricing