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10.1111/cas.13148 http://scihub22266oqcxt.onion/10.1111/cas.13148 C5378261!5378261!28012229     free     free     free Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cancer+Sci 2017 ; 108 (3): 536-42 Nephropedia Template TP {{tp|p=28012229|t=2017. miR?3941: A novel microRNA that controls IGBP1 expression and is associated with malignant progression of lung adenocarcinoma |pdf=|usr=}}{{28012229}} gab.com Text miR 3941: A novel microRNA that controls IGBP1 expression and is associated with malignant progression of lung adenocarcinoma JO: Cancer Sci http://www.kidney.de/pget.php?&tw=1&pmid=28012229 #FOAvip Immunoglobulin (CD79a) binding protein 1 (IGBP1) is universally overexpressed in lung adenocarcinoma and exerts an anti?apoptotic effect by binding to PP2Ac. However, the molecular mechanism of IGBP1 overexpression is still unclear. In the present study, we used a microRNA (miRNA) array and TargetScan Human software to detect IGBP1?related miRNAs that regulate IGBP1 expression. The miRNA array analysis revealed more than 100 miRNAs that are dysregulated in early invasive adenocarcinoma. On the other hand, in silico analysis using TargetScan Human revealed 79 miRNAs that are associated with IGBP1 protein expression. Among the miRNAs selected by miRNA array analysis, six (miR?34b, miR?138, miR?374a, miR?374b, miR?1909, miR?3941) were also included among those selected by TargetScan analysis. Real?time reverse transcription PCR (real?time RT?PCR) showed that the six microRNAs were downregulated in invasive adenocarcinoma (IGBP1+) relative to adjacent normal lung tissue (IGBP1?). Among these microRNAs, only miR?34b and miR?3941 depressed luciferase activity by targeting 3?UTR?IGBP1 in the luciferase vector. We transfected miR?34b and miR?3941 into lung adenocarcinoma cell lines (A549, PC?9), and both of them suppressed IGBP1 expression and cell proliferation. Moreover, the transfected miR?34b and miR?3941 induced apoptosis of a lung adenocarcinoma cell line, similarly to the effect of siIGBP1 RNA. As well as miR?34b, we found that miR?3941 targeted IGBP1 specifically and was able to exclusively downregulate IGBP1 expression. These findings indicate that suppression of miR?3941 has an important role in the progression of lung adenocarcinoma at an early stage. Twit Text FOAVip miR 3941: A novel microRNA that controls IGBP1 expression and is associated with malignant progression of lung adenocarcinoma ????Cancer Sci http://www.kidney.de/pget.php?&tw=1&pmid=28012229 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28012229 #FOAvip English Wikipedia <ref>{{Cite pmid|28012229}}</ref> miR?3941: A novel microRNA that controls IGBP1 expression and is associated with malignant progression of lung adenocarcinoma #MMPMID28012229 Sato T; Shiba?Ishii A; Kim Y; Dai T; Husni RE; Hong J; Kano J; Sakashita S; Iijima T; Noguchi M Cancer Sci 2017[Mar]; 108 (3): 536-42 PMID28012229show ga Immunoglobulin (CD79a) binding protein 1 (IGBP1) is universally overexpressed in lung adenocarcinoma and exerts an anti?apoptotic effect by binding to PP2Ac. However, the molecular mechanism of IGBP1 overexpression is still unclear. In the present study, we used a microRNA (miRNA) array and TargetScan Human software to detect IGBP1?related miRNAs that regulate IGBP1 expression. The miRNA array analysis revealed more than 100 miRNAs that are dysregulated in early invasive adenocarcinoma. On the other hand, in silico analysis using TargetScan Human revealed 79 miRNAs that are associated with IGBP1 protein expression. Among the miRNAs selected by miRNA array analysis, six (miR?34b, miR?138, miR?374a, miR?374b, miR?1909, miR?3941) were also included among those selected by TargetScan analysis. Real?time reverse transcription PCR (real?time RT?PCR) showed that the six microRNAs were downregulated in invasive adenocarcinoma (IGBP1+) relative to adjacent normal lung tissue (IGBP1?). Among these microRNAs, only miR?34b and miR?3941 depressed luciferase activity by targeting 3?UTR?IGBP1 in the luciferase vector. We transfected miR?34b and miR?3941 into lung adenocarcinoma cell lines (A549, PC?9), and both of them suppressed IGBP1 expression and cell proliferation. Moreover, the transfected miR?34b and miR?3941 induced apoptosis of a lung adenocarcinoma cell line, similarly to the effect of siIGBP1 RNA. As well as miR?34b, we found that miR?3941 targeted IGBP1 specifically and was able to exclusively downregulate IGBP1 expression. These findings indicate that suppression of miR?3941 has an important role in the progression of lung adenocarcinoma at an early stage. ämiR?3941: A novel microRNA that controls IGBP1 expression and is assoc(epmc).pdf DeepDyve Pubget Overpricing