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10.1098/rsif.2017.0032 http://scihub22266oqcxt.onion/10.1098/rsif.2017.0032 C5378146!5378146!28330988     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+R+Soc+Interface 2017 ; 14 (128): ä Nephropedia Template TP {{tp|p=28330988|t=2017. Cell-size distribution in epithelial tissue formation and homeostasis |pdf=|usr=}}{{28330988}} gab.com Text Cell-size distribution in epithelial tissue formation and homeostasis JO: J R Soc Interface http://www.kidney.de/pget.php?&tw=1&pmid=28330988 #FOAvip How cell growth and proliferation are orchestrated in living tissues to achieve a given biological function is a central problem in biology. During development, tissue regeneration and homeostasis, cell proliferation must be coordinated by spatial cues in order for cells to attain the correct size and shape. Biological tissues also feature a notable homogeneity of cell size, which, in specific cases, represents a physiological need. Here, we study the temporal evolution of the cell-size distribution by applying the theory of kinetic fragmentation to tissue development and homeostasis. Our theory predicts self-similar probability density function (PDF) of cell size and explains how division times and redistribution ensure cell size homogeneity across the tissue. Theoretical predictions and numerical simulations of confluent non-homeostatic tissue cultures show that cell size distribution is self-similar. Our experimental data confirm predictions and reveal that, as assumed in the theory, cell division times scale like a power-law of the cell size. We find that in homeostatic conditions there is a stationary distribution with lognormal tails, consistently with our experimental data. Our theoretical predictions and numerical simulations show that the shape of the PDF depends on how the space inherited by apoptotic cells is redistributed and that apoptotic cell rates might also depend on size. Twit Text FOAVip Cell-size distribution in epithelial tissue formation and homeostasis ????J R Soc Interface http://www.kidney.de/pget.php?&tw=1&pmid=28330988 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28330988 #FOAvip English Wikipedia <ref>{{Cite pmid|28330988}}</ref> Cell-size distribution in epithelial tissue formation and homeostasis #MMPMID28330988 Puliafito A; Primo L; Celani A J R Soc Interface 2017[Mar]; 14 (128): ä PMID28330988show ga How cell growth and proliferation are orchestrated in living tissues to achieve a given biological function is a central problem in biology. During development, tissue regeneration and homeostasis, cell proliferation must be coordinated by spatial cues in order for cells to attain the correct size and shape. Biological tissues also feature a notable homogeneity of cell size, which, in specific cases, represents a physiological need. Here, we study the temporal evolution of the cell-size distribution by applying the theory of kinetic fragmentation to tissue development and homeostasis. Our theory predicts self-similar probability density function (PDF) of cell size and explains how division times and redistribution ensure cell size homogeneity across the tissue. Theoretical predictions and numerical simulations of confluent non-homeostatic tissue cultures show that cell size distribution is self-similar. Our experimental data confirm predictions and reveal that, as assumed in the theory, cell division times scale like a power-law of the cell size. We find that in homeostatic conditions there is a stationary distribution with lognormal tails, consistently with our experimental data. Our theoretical predictions and numerical simulations show that the shape of the PDF depends on how the space inherited by apoptotic cells is redistributed and that apoptotic cell rates might also depend on size. äCell-size distribution in epithelial tissue formation and homeostasis (epmc).pdf DeepDyve Pubget Overpricing