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2017 ; 9
(3-4
): 67-72
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gab.com Text
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Bovine serum albumin-glutaraldehyde (BioGlue(®)) tissue adhesive versus standard
renorrhaphy following renal mass enucleation: a retrospective comparison
#MMPMID28392835
Bahouth Z
; Moskovitz B
; Halachmi S
; Nativ O
Ther Adv Urol
2017[Mar]; 9
(3-4
): 67-72
PMID28392835
show ga
BACKGROUND: To present the operative and post-operative comparison between
patients who underwent tumor-bed closure with sutures compared with bovine serum
albumin-glutaraldehyde (BioGlue(®)) tissue sealant only. METHODS: We
retrospectively analyzed data from our ongoing database of 507 eligible patients
who underwent open NSS nephron-sparing surgery in our department between January
1995 and May 2014. Patients had tumor-bed closure with sealant adhesive (255
patients) or standard suture technique (252 patients). Demographic, clinical and
perioperative data were compared between the two groups, by Chi-square test or by
Fisher-Irwin exact test for categorical variables, and by t test for differences
in means or by Wilcoxon rank sum test for continuous variables. A multivariate
analysis was also done. RESULTS: Patients' baseline characteristics showed
similar distribution of the analyzed parameters among both groups, with few
differences: younger age in the sealant group (65.4 versus 68.4 years, p = 0.01)
and slightly larger mass size in the suture group (4.0 versus 3.9 cm, p = 0.03).
Ischemia time was significantly shorter in the sealant group (21.8 versus 27.0
minutes, p = 0001). Blood loss and transfusion rate (0.8% versus 11.9%, p =
0.0001) were significantly less in the sealant group. A multivariate analysis
showed date of surgery and blood loss as the major parameters affecting
transfusion rate. CONCLUSIONS: Closing the tumor bed with BioGlue(®) tissue
adhesive is feasible, safe, can shorten ischemia time and potentially reduce
transfusion rate.