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suck abstract from ncbi


10.1101/cshperspect.a026450

http://scihub22266oqcxt.onion/10.1101/cshperspect.a026450
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C5378010!5378010!28096241
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suck abstract from ncbi


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pmid28096241      Cold+Spring+Harb+Perspect+Med 2017 ; 7 (4): ä
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  • The Chromodomain Helicase DNA-Binding Chromatin Remodelers: Family Traits that Protect from and Promote Cancer #MMPMID28096241
  • Mills AA
  • Cold Spring Harb Perspect Med 2017[Apr]; 7 (4): ä PMID28096241show ga
  • A plethora of mutations in chromatin regulators in diverse human cancers is emerging, attesting to the pivotal role of chromatin dynamics in tumorigenesis. A recurrent theme is inactivation of the chromodomain helicase DNA-binding (CHD) family of proteins?ATP-dependent chromatin remodelers that govern the cellular machinery?s access to DNA, thereby controlling fundamental processes, including transcription, proliferation, and DNA damage repair. This review highlights what is currently known about how genetic and epigenetic perturbation of CHD proteins and the pathways that they regulate set the stage for cancer, providing new insight for designing more effective anti-cancer therapies.
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