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10.1038/srep45789 http://scihub22266oqcxt.onion/10.1038/srep45789 C5377939!5377939!28368012     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Sci+Rep 2017 ; 7 (ä): ä Nephropedia Template TP {{tp|p=28368012|t=2017. Illuminating dynamic neutrophil trans-epithelial migration with micro-optical coherence tomography |pdf=|usr=}}{{28368012}} gab.com Text Illuminating dynamic neutrophil trans-epithelial migration with micro-optical coherence tomography JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=28368012 #FOAvip A model of neutrophil migration across epithelia is desirable to interrogate the underlying mechanisms of neutrophilic breach of mucosal barriers. A co-culture system consisting of a polarized mucosal epithelium and human neutrophils can provide a versatile model of trans-epithelial migration in vitro, but observations are typically limited to quantification of migrated neutrophils by myeloperoxidase correlation, a destructive assay that precludes direct longitudinal study. Our laboratory has recently developed a new isotropic 1-?m resolution optical imaging technique termed micro-optical coherence tomography (?OCT) that enables 4D (x,y,z,t) visualization of neutrophils in the co-culture environment. By applying ?OCT to the trans-epithelial migration model, we can robustly monitor the spatial distribution as well as the quantity of neutrophils chemotactically crossing the epithelial boundary over time. Here, we demonstrate the imaging and quantitative migration results of our system as applied to neutrophils migrating across intestinal epithelia in response to a chemoattractant. We also demonstrate that perturbation of a key molecular event known to be critical for effective neutrophil trans-epithelial migration (CD18 engagement) substantially impacts this process both qualitatively and quantitatively. Twit Text FOAVip Illuminating dynamic neutrophil trans-epithelial migration with micro-optical coherence tomography ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=28368012 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28368012 #FOAvip English Wikipedia <ref>{{Cite pmid|28368012}}</ref> Illuminating dynamic neutrophil trans-epithelial migration with micro-optical coherence tomography #MMPMID28368012 Chu KK; Kusek ME; Liu L; Som A; Yonker LM; Leung H; Cui D; Ryu J; Eaton AD; Tearney GJ; Hurley BP Sci Rep 2017[]; 7 (ä): ä PMID28368012show ga A model of neutrophil migration across epithelia is desirable to interrogate the underlying mechanisms of neutrophilic breach of mucosal barriers. A co-culture system consisting of a polarized mucosal epithelium and human neutrophils can provide a versatile model of trans-epithelial migration in vitro, but observations are typically limited to quantification of migrated neutrophils by myeloperoxidase correlation, a destructive assay that precludes direct longitudinal study. Our laboratory has recently developed a new isotropic 1-?m resolution optical imaging technique termed micro-optical coherence tomography (?OCT) that enables 4D (x,y,z,t) visualization of neutrophils in the co-culture environment. By applying ?OCT to the trans-epithelial migration model, we can robustly monitor the spatial distribution as well as the quantity of neutrophils chemotactically crossing the epithelial boundary over time. Here, we demonstrate the imaging and quantitative migration results of our system as applied to neutrophils migrating across intestinal epithelia in response to a chemoattractant. We also demonstrate that perturbation of a key molecular event known to be critical for effective neutrophil trans-epithelial migration (CD18 engagement) substantially impacts this process both qualitatively and quantitatively. äIlluminating dynamic neutrophil trans-epithelial migration with micro-(epmc).pdf DeepDyve Pubget Overpricing