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10.1074/jbc.M116.757666 http://scihub22266oqcxt.onion/10.1074/jbc.M116.757666 C5377787!5377787 !28174303     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28174303 &cmd=llinks): Failed to open stream: HTTP request failed! 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Central Regulatory Role for SIN1 in Interferon ? (IFN?) Signaling and Generation of Biological Responses |pdf=|usr=}}{{28174303 }} gab.com Text Central Regulatory Role for SIN1 in Interferon (IFN ) Signaling and Generation of Biological Responses JO: J Biol Chem http://www.kidney.de/pget.php?&tw=1&pmid=28174303 #FOAvip The precise signaling mechanisms by which type II IFN receptors control expression of unique genes to induce biological responses remain to be established. We provide evidence that Sin1, a known element of the mammalian target of rapamycin complex 2 (mTORC2), is required for IFN?-induced phosphorylation and activation of AKT and that such activation mediates downstream regulation of mTORC1 and its effectors. These events play important roles in the assembly of the eukaryotic translation initiation factor 4F (eIF4F) and mRNA translation of IFN-stimulated genes. Interestingly, IFN?-induced tyrosine phosphorylation of STAT1 is reduced in cells with targeted disruption of Sin1, leading to decreased transcription of several IFN?-inducible genes in an mTORC2-independent manner. Additionally, our studies establish that Sin1 is essential for generation of type II IFN-dependent antiviral effects and antiproliferative responses in normal and malignant hematopoiesis. Together, our findings establish an important role for Sin1 in both transcription and translation of IFN-stimulated genes and type II IFN-mediated biological responses, involving both mTORC2-dependent and -independent functions. Twit Text FOAVip Central Regulatory Role for SIN1 in Interferon (IFN ) Signaling and Generation of Biological Responses ????J Biol Chem http://www.kidney.de/pget.php?&tw=1&pmid=28174303 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28174303 #FOAvip English Wikipedia <ref>{{Cite pmid|28174303 }}</ref> Central Regulatory Role for SIN1 in Interferon ? (IFN?) Signaling and Generation of Biological Responses #MMPMID28174303 Kroczynska B ; Blyth GT ; Rafidi RL ; Majchrzak-Kita B ; Xu L ; Saleiro D ; Kosciuczuk EM ; Jemielity J ; Su B ; Altman JK ; Eklund EA ; Fish EN ; Platanias LC J Biol Chem 2017[Mar]; 292 (11 ): 4743-4752 PMID28174303 show ga The precise signaling mechanisms by which type II IFN receptors control expression of unique genes to induce biological responses remain to be established. We provide evidence that Sin1, a known element of the mammalian target of rapamycin complex 2 (mTORC2), is required for IFN?-induced phosphorylation and activation of AKT and that such activation mediates downstream regulation of mTORC1 and its effectors. These events play important roles in the assembly of the eukaryotic translation initiation factor 4F (eIF4F) and mRNA translation of IFN-stimulated genes. Interestingly, IFN?-induced tyrosine phosphorylation of STAT1 is reduced in cells with targeted disruption of Sin1, leading to decreased transcription of several IFN?-inducible genes in an mTORC2-independent manner. Additionally, our studies establish that Sin1 is essential for generation of type II IFN-dependent antiviral effects and antiproliferative responses in normal and malignant hematopoiesis. Together, our findings establish an important role for Sin1 in both transcription and translation of IFN-stimulated genes and type II IFN-mediated biological responses, involving both mTORC2-dependent and -independent functions. |Adaptor Proteins, Signal Transducing/*immunology [MESH] |Animals [MESH] |Carrier Proteins/*immunology [MESH] |Cell Line [MESH] |Humans [MESH] |Immunity, Innate [MESH] |Interferon-gamma/*immunology [MESH] |Mice [MESH] |Phosphorylation [MESH] |Proto-Oncogene Proteins c-akt/chemistry/immunology [MESH] |STAT1 Transcription Factor/chemistry/immunology [MESH]Central Regulatory Role for SIN1 in Interferon ? (IFN?) Signaling and (epmc).pdf DeepDyve Pubget Overpricing