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10.1074/jbc.M116.771105 http://scihub22266oqcxt.onion/10.1074/jbc.M116.771105 C5377769!5377769!28082677     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Biol+Chem 2017 ; 292 (11): 4519-32 Nephropedia Template TP {{tp|p=28082677|t=2017. The Pseudouridine Synthase RPUSD4 Is an Essential Component of Mitochondrial RNA Granules* |pdf=|usr=}}{{28082677}} gab.com Text The Pseudouridine Synthase RPUSD4 Is an Essential Component of Mitochondrial RNA Granules* JO: J Biol Chem http://www.kidney.de/pget.php?&tw=1&pmid=28082677 #FOAvip Mitochondrial gene expression is a fundamental process that is largely dependent on nuclear-encoded proteins. Several steps of mitochondrial RNA processing and maturation, including RNA post-transcriptional modification, appear to be spatially organized into distinct foci, which we have previously termed mitochondrial RNA granules (MRGs). Although an increasing number of proteins have been localized to MRGs, a comprehensive analysis of the proteome of these structures is still lacking. Here, we have applied a microscopy-based approach that has allowed us to identify novel components of the MRG proteome. Among these, we have focused our attention on RPUSD4, an uncharacterized mitochondrial putative pseudouridine synthase. We show that RPUSD4 depletion leads to a severe reduction of the steady-state level of the 16S mitochondrial (mt) rRNA with defects in the biogenesis of the mitoribosome large subunit and consequently in mitochondrial translation. We report that RPUSD4 binds 16S mt-rRNA, mt-tRNAMet, and mt-tRNAPhe, and we demonstrate that it is responsible for pseudouridylation of the latter. These data provide new insights into the relevance of RNA pseudouridylation in mitochondrial gene expression. Twit Text FOAVip The Pseudouridine Synthase RPUSD4 Is an Essential Component of Mitochondrial RNA Granules* ????J Biol Chem http://www.kidney.de/pget.php?&tw=1&pmid=28082677 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28082677 #FOAvip English Wikipedia <ref>{{Cite pmid|28082677}}</ref> The Pseudouridine Synthase RPUSD4 Is an Essential Component of Mitochondrial RNA Granules* #MMPMID28082677 Zaganelli S; Rebelo-Guiomar P; Maundrell K; Rozanska A; Pierredon S; Powell CA; Jourdain AA; Hulo N; Lightowlers RN; Chrzanowska-Lightowlers ZM; Minczuk M; Martinou JC J Biol Chem 2017[Mar]; 292 (11): 4519-32 PMID28082677show ga Mitochondrial gene expression is a fundamental process that is largely dependent on nuclear-encoded proteins. Several steps of mitochondrial RNA processing and maturation, including RNA post-transcriptional modification, appear to be spatially organized into distinct foci, which we have previously termed mitochondrial RNA granules (MRGs). Although an increasing number of proteins have been localized to MRGs, a comprehensive analysis of the proteome of these structures is still lacking. Here, we have applied a microscopy-based approach that has allowed us to identify novel components of the MRG proteome. Among these, we have focused our attention on RPUSD4, an uncharacterized mitochondrial putative pseudouridine synthase. We show that RPUSD4 depletion leads to a severe reduction of the steady-state level of the 16S mitochondrial (mt) rRNA with defects in the biogenesis of the mitoribosome large subunit and consequently in mitochondrial translation. We report that RPUSD4 binds 16S mt-rRNA, mt-tRNAMet, and mt-tRNAPhe, and we demonstrate that it is responsible for pseudouridylation of the latter. These data provide new insights into the relevance of RNA pseudouridylation in mitochondrial gene expression. äThe Pseudouridine Synthase RPUSD4 Is an Essential Component of Mitocho(epmc).pdf DeepDyve Pubget Overpricing