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2017 ; 13
(4
): 1630-1633
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Prognosis of patients with Acinetobacter baumannii infection in the intensive
care unit: A retrospective analysis
#MMPMID28413520
Xiao D
; Wang L
; Zhang D
; Xiang D
; Liu Q
; Xing X
Exp Ther Med
2017[Apr]; 13
(4
): 1630-1633
PMID28413520
show ga
The present retrospective study aimed to investigate the prognostic factors for
critically ill patients with an Acinetobacter baumannii (A. baumannii) infection.
A total of 37 patients from the intensive care unit (ICU) were enrolled in the
study. Data was collected from patients, including age, gender, ethnicity, A.
baumannii infection status, concurrent infection status, prescribed antibiotics,
Acute Physiology and Chronic Health Evaluation II (APACHE II) and sepsis-related
organ failure assessment (SOFA) scores, procalcitonin level, site of infection,
shock, sepsis and renal replacement therapy status. Univariate and multivariate
analyses were performed to determine the prognostic factors for mortality. In
total, 8 out of the 37 patients included in this trial did not survive, resulting
in an ICU mortality rate of 21.6%. Univariate analysis indicated that, in
comparison with the survival group, APACHE II and SOFA scores were significantly
higher in the mortality group (P<0.002 and P<0.001, respectively). A larger
number of patients with septic shock were detected in the mortality group in
comparison with the survival group (n=4 and n=3, respectively), whereas a larger
number of patients were infected with multidrug-resistant A. baumannii (MDRAB) in
the survival group in comparison with the mortality group (51.9 and 14.3%,
respectively). However, the prognosis was not significantly influenced by
antibiotics administered, mixed infection or the site of infection. Multivariate
analysis demonstrated that the APACHE II score was the only independent factor
affecting the disease prognosis. Receiver operating characteristic curve analysis
of the APACHE II score demonstrated that the area under the curve was
0.845±0.078. In patients with an APACHE II score of 15, the sensitivity and
specificity predictions for mortality were 87.5% and 72.4%, respectively. The
APACHE II score at diagnosis was the only independent factor found to assist in
the prognosis of mortality for patients in the ICU with an A. baumannii
infection. In conclusion, the results of the present study demonstrated that the
APACHE II score may contribute towards the prognostic evaluation of patients in
the ICU with an A. baumannii infection.