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2017 ; 7
(4
): 562-576
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Suppression of a single pair of mushroom body output neurons in Drosophila
triggers aversive associations
#MMPMID28396840
Ueoka Y
; Hiroi M
; Abe T
; Tabata T
FEBS Open Bio
2017[Apr]; 7
(4
): 562-576
PMID28396840
show ga
Memory includes the processes of acquisition, consolidation and retrieval. In the
study of aversive olfactory memory in Drosophila melanogaster, flies are first
exposed to an odor (conditioned stimulus, CS+) that is associated with an
electric shock (unconditioned stimulus, US), then to another odor (CS-) without
the US, before allowing the flies to choose to avoid one of the two odors. The
center for memory formation is the mushroom body which consists of Kenyon cells
(KCs), dopaminergic neurons (DANs) and mushroom body output neurons (MBONs).
However, the roles of individual neurons are not fully understood. We focused on
the role of a single pair of GABAergic neurons (MBON-?1pedc) and found that it
could inhibit the effects of DANs, resulting in the suppression of aversive
memory acquisition during the CS- odor presentation, but not during the CS+ odor
presentation. We propose that MBON-?1pedc suppresses the DAN-dependent effect
that can convey the aversive US during the CS- odor presentation, and thereby
prevents an insignificant stimulus from becoming an aversive US.