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10.1002/2211-5463.12180 http://scihub22266oqcxt.onion/10.1002/2211-5463.12180 C5377406!5377406!28396833     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       FEBS+Open+Bio 2017 ; 7 (4): 477-84 Nephropedia Template TP {{tp|p=28396833|t=2017. Activation of PPAR? by baicalin attenuates pulmonary hypertension in an infant rat model by suppressing HMGB1/RAGE signaling |pdf=|usr=}}{{28396833}} gab.com Text Activation of PPAR by baicalin attenuates pulmonary hypertension in an infant rat model by suppressing HMGB1/RAGE signaling JO: FEBS Open Bio http://www.kidney.de/pget.php?&tw=1&pmid=28396833 #FOAvip Pulmonary hypertension (PH) is a vascular disease, and proinflammatory factors are strongly implicated in its pathogenesis, causing right ventricular (RV) hypertrophy and heart failure. Baicalin exhibits potent anti?inflammation activity. This study aimed to investigate the curative effects of baicalin in an infant rodent model of PH and to further explore the underlying mechanisms. A PH model in infant rats was induced by hypoxia and the resulting rats were administered baicalin in incremental dosages. Invasive hemodynamic methods were used to measure mean pulmonary arterial pressure (mPAP) and RV end?diastolic pressure (RVEDP). RV hypertrophy was assessed by mass pathology and histology. ELISAs were used to determine concentrations of high?mobility group box 1 (HMGB1), secretory receptor for advanced glycation end products (sRAGE), interleukin 6 (IL6) and transforming growth factor ? (TGF?1) in bronchoalveolar lavage fluid (BALF). Electrophoretic mobility shift and phosphorylation in nuclear extracts were used to evaluate the activation of peroxisome proliferator?activated receptor ? (PPAR?). Western blotting was used to detect the expression levels of heme oxygenase 1 (HO1), HMGB1, RAGE, IL6 and TGF?1 in lung tissue. Baicalin administration significantly attenuated mPAP, RVEDP and RV hypertrophy in infant rats with PH. HMGB1, sRAGE, IL6 and TGF?1 levels in BALF were also reduced by baicalin treatment. Baicalin activated PPAR?, which promoted expression of HO1. Furthermore, expression levels of HMGB1, RAGE, IL6 and TGF?1 in lung tissue were dramatically decreased by baicalin in a dosage?dependent manner. Baicalin showed curative effects in infant rats with PH. Activation of PPAR? that inhibited HMGB1/RAGE inflammatory signaling was involved. Twit Text FOAVip Activation of PPAR by baicalin attenuates pulmonary hypertension in an infant rat model by suppressing HMGB1/RAGE signaling ????FEBS Open Bio http://www.kidney.de/pget.php?&tw=1&pmid=28396833 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28396833 #FOAvip English Wikipedia <ref>{{Cite pmid|28396833}}</ref> Activation of PPAR? by baicalin attenuates pulmonary hypertension in an infant rat model by suppressing HMGB1/RAGE signaling #MMPMID28396833 Chen Z; Wang Q FEBS Open Bio 2017[Apr]; 7 (4): 477-84 PMID28396833show ga Pulmonary hypertension (PH) is a vascular disease, and proinflammatory factors are strongly implicated in its pathogenesis, causing right ventricular (RV) hypertrophy and heart failure. Baicalin exhibits potent anti?inflammation activity. This study aimed to investigate the curative effects of baicalin in an infant rodent model of PH and to further explore the underlying mechanisms. A PH model in infant rats was induced by hypoxia and the resulting rats were administered baicalin in incremental dosages. Invasive hemodynamic methods were used to measure mean pulmonary arterial pressure (mPAP) and RV end?diastolic pressure (RVEDP). RV hypertrophy was assessed by mass pathology and histology. ELISAs were used to determine concentrations of high?mobility group box 1 (HMGB1), secretory receptor for advanced glycation end products (sRAGE), interleukin 6 (IL6) and transforming growth factor ? (TGF?1) in bronchoalveolar lavage fluid (BALF). Electrophoretic mobility shift and phosphorylation in nuclear extracts were used to evaluate the activation of peroxisome proliferator?activated receptor ? (PPAR?). Western blotting was used to detect the expression levels of heme oxygenase 1 (HO1), HMGB1, RAGE, IL6 and TGF?1 in lung tissue. Baicalin administration significantly attenuated mPAP, RVEDP and RV hypertrophy in infant rats with PH. HMGB1, sRAGE, IL6 and TGF?1 levels in BALF were also reduced by baicalin treatment. Baicalin activated PPAR?, which promoted expression of HO1. Furthermore, expression levels of HMGB1, RAGE, IL6 and TGF?1 in lung tissue were dramatically decreased by baicalin in a dosage?dependent manner. Baicalin showed curative effects in infant rats with PH. Activation of PPAR? that inhibited HMGB1/RAGE inflammatory signaling was involved. äActivation of PPAR? by baicalin attenuates pulmonary hypertension in a(epmc).pdf DeepDyve Pubget Overpricing