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10.1002/2211-5463.12205 http://scihub22266oqcxt.onion/10.1002/2211-5463.12205 C5377400!5377400!28396842     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       FEBS+Open+Bio 2017 ; 7 (4): 587-601 Nephropedia Template TP {{tp|p=28396842|t=2017. Uptake of 3?iodothyronamine hormone analogs inhibits the growth and viability of cancer cells |pdf=|usr=}}{{28396842}} gab.com Text Uptake of 3 iodothyronamine hormone analogs inhibits the growth and viability of cancer cells JO: FEBS Open Bio http://www.kidney.de/pget.php?&tw=1&pmid=28396842 #FOAvip 3?Iodothyronamine (T1AM) is a structural analog of thyroid hormone that has been demonstrated to have potent affects on numerous physiological systems. Most studies on T1AM have explored its effects in healthy functional systems; while its potential therapeutic uses and safety, and efficacy in pathological conditions are largely unknown. We sought to evaluate the effects of T1AM and its structural analog SG?2 on cancer cell growth and viability. We analyzed the cytotoxicity of these analogs on MCF7 breast cancer cells, HepG2 hepatocellular cancer cells as well as normal control cells using primary human foreskin fibroblasts and mouse preadipocytes control cells. The cytotoxicity of T1AM and SG?2 was determined by cell growth curves, and validated by 3?(4,5?dimethylthiazol?2?yl)?2,5?diphenyltetrazolium bromide cell viability assays. Cellular uptake analysis was conducted using confocal microscopy. Real?time (RT)?PCR was conducted to identify gene pathways affected by SG?2 in cancer cells. The IC50 of T1AM was approximately double the concentration of its analog SG?2 in cancer cells. Cytotoxicity studies on normal cells revealed that IC50 concentrations of SG?2 in cancer cells had no significant impact on cell viability in these cell types. Cell?imaging experiments demonstrated rapid uptake and localization to the mitochondrial membrane. T1AM and SG?2 are able to reduce cancer cell growth and viability. These findings support the potential for use of these compounds and related analogs for their antiproliferation properties in cancer cells. Twit Text FOAVip Uptake of 3 iodothyronamine hormone analogs inhibits the growth and viability of cancer cells ????FEBS Open Bio http://www.kidney.de/pget.php?&tw=1&pmid=28396842 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28396842 #FOAvip English Wikipedia <ref>{{Cite pmid|28396842}}</ref> Uptake of 3?iodothyronamine hormone analogs inhibits the growth and viability of cancer cells #MMPMID28396842 Rogowski M; Gollahon L; Chellini G; Assadi?Porter FM FEBS Open Bio 2017[Apr]; 7 (4): 587-601 PMID28396842show ga 3?Iodothyronamine (T1AM) is a structural analog of thyroid hormone that has been demonstrated to have potent affects on numerous physiological systems. Most studies on T1AM have explored its effects in healthy functional systems; while its potential therapeutic uses and safety, and efficacy in pathological conditions are largely unknown. We sought to evaluate the effects of T1AM and its structural analog SG?2 on cancer cell growth and viability. We analyzed the cytotoxicity of these analogs on MCF7 breast cancer cells, HepG2 hepatocellular cancer cells as well as normal control cells using primary human foreskin fibroblasts and mouse preadipocytes control cells. The cytotoxicity of T1AM and SG?2 was determined by cell growth curves, and validated by 3?(4,5?dimethylthiazol?2?yl)?2,5?diphenyltetrazolium bromide cell viability assays. Cellular uptake analysis was conducted using confocal microscopy. Real?time (RT)?PCR was conducted to identify gene pathways affected by SG?2 in cancer cells. The IC50 of T1AM was approximately double the concentration of its analog SG?2 in cancer cells. Cytotoxicity studies on normal cells revealed that IC50 concentrations of SG?2 in cancer cells had no significant impact on cell viability in these cell types. Cell?imaging experiments demonstrated rapid uptake and localization to the mitochondrial membrane. T1AM and SG?2 are able to reduce cancer cell growth and viability. These findings support the potential for use of these compounds and related analogs for their antiproliferation properties in cancer cells. äUptake of 3?iodothyronamine hormone analogs inhibits the growth and vi(epmc).pdf DeepDyve Pubget Overpricing