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10.3892/etm.2017.4130 http://scihub22266oqcxt.onion/10.3892/etm.2017.4130 C5377337!5377337 !28413484     free     free     free Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28413484 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Exp+Ther+Med 2017 ; 13 (4 ): 1398-1402 Nephropedia Template TP {{tp|p=28413484 |t=2017. Inhibitor ?B? protein therapy alleviates severe pneumonia through inhibition of nuclear factor ?B |pdf=|usr=}}{{28413484 }} gab.com Text Inhibitor B protein therapy alleviates severe pneumonia through inhibition of nuclear factor B JO: Exp Ther Med http://www.kidney.de/pget.php?&tw=1&pmid=28413484 #FOAvip To investigate the effect of inhibitor ?B? (I?B?) on severe pneumonia and explain the mechanisms of nuclear factor ?B (NF-?B), the activation of NF-?B was induced in Sprague-Dawley (SD) rats infected with Klebsiella pneumoniae (K. pneumoniae). The rats were then treated with differing concentrations of I?B? protein. A histological analysis was performed to compare the lung structure prior to and following treatment, and an immunohistochemistry assay was used to detect NF-?B activity. In addition, the expression of certain inflammatory factors was detected using a protein chip assay. The severe pneumonia rat model was successfully produced and in model rats, NF-?B was activated by K. pneumoniae. Following treatment with I?B?, the activity of NF-?B was inhibited and pneumonia symptoms in model rats were alleviated. Furthermore, the expression of a number of inflammatory factors including tumor necrosis factor ? (TNF-?), interleukin 6 (IL-6), interferon ? (IFN-?) and monocyte chemoattractant protein-1 (MCP-1) were also inhibited. The current study demonstrates that NF-?B inhibition with I?B? protein therapy prevents the development of pneumonia in a K. pneumoniae rat model. The therapeutic effect is indicated by the responses of proinflammatory factors, including TNF-?, IL-6, IFN-? and MCP-1. Twit Text FOAVip Inhibitor B protein therapy alleviates severe pneumonia through inhibition of nuclear factor B ????Exp Ther Med http://www.kidney.de/pget.php?&tw=1&pmid=28413484 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28413484 #FOAvip English Wikipedia <ref>{{Cite pmid|28413484 }}</ref> Inhibitor ?B? protein therapy alleviates severe pneumonia through inhibition of nuclear factor ?B #MMPMID28413484 Xu H ; Mei B ; Wang M ; Xu S Exp Ther Med 2017[Apr]; 13 (4 ): 1398-1402 PMID28413484 show ga To investigate the effect of inhibitor ?B? (I?B?) on severe pneumonia and explain the mechanisms of nuclear factor ?B (NF-?B), the activation of NF-?B was induced in Sprague-Dawley (SD) rats infected with Klebsiella pneumoniae (K. pneumoniae). The rats were then treated with differing concentrations of I?B? protein. A histological analysis was performed to compare the lung structure prior to and following treatment, and an immunohistochemistry assay was used to detect NF-?B activity. In addition, the expression of certain inflammatory factors was detected using a protein chip assay. The severe pneumonia rat model was successfully produced and in model rats, NF-?B was activated by K. pneumoniae. Following treatment with I?B?, the activity of NF-?B was inhibited and pneumonia symptoms in model rats were alleviated. Furthermore, the expression of a number of inflammatory factors including tumor necrosis factor ? (TNF-?), interleukin 6 (IL-6), interferon ? (IFN-?) and monocyte chemoattractant protein-1 (MCP-1) were also inhibited. The current study demonstrates that NF-?B inhibition with I?B? protein therapy prevents the development of pneumonia in a K. pneumoniae rat model. The therapeutic effect is indicated by the responses of proinflammatory factors, including TNF-?, IL-6, IFN-? and MCP-1. äInhibitor ?B? protein therapy alleviates severe pneumonia through inhi(epmc).pdf DeepDyve Pubget Overpricing