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10.1021/acsomega.6b00436 http://scihub22266oqcxt.onion/10.1021/acsomega.6b00436 C5377267!5377267!28393131     free     free     free Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       ACS+Omega 2017 ; 2 (3): 937-45 Nephropedia Template TP {{tp|p=28393131|t=2017. Controlling T-Cell Activation with Synthetic Dendritic Cells Using the Multivalency Effect |pdf=|usr=}}{{28393131}} gab.com Text Controlling T-Cell Activation with Synthetic Dendritic Cells Using the Multivalency Effect JO: ACS Omega http://www.kidney.de/pget.php?&tw=1&pmid=28393131 #FOAvip Artificial antigen-presenting cells (aAPCs) have recently gained a lot of attention. They efficiently activate T cells and serve as powerful replacements for dendritic cells in cancer immunotherapy. Focusing on a specific class of polymer-based aAPCs, so-called synthetic dendritic cells (sDCs), we have investigated the importance of multivalent binding on T-cell activation. Using antibody-functionalized sDCs, we have tested the influence of polymer length and antibody density. Increasing the multivalent character of the antibody-functionalized polymer lowered the effective concentration required for T-cell activation. This was evidenced for both early and late stages of activation. The most important effect observed was the significantly prolonged activation of the stimulated T cells, indicating that multivalent sDCs sustain T-cell signaling. Our results highlight the importance of multivalency for the design of aAPCs and will ultimately allow for better mimics of natural dendritic cells that can be used as vaccines in cancer treatment. Twit Text FOAVip Controlling T-Cell Activation with Synthetic Dendritic Cells Using the Multivalency Effect ????ACS Omega http://www.kidney.de/pget.php?&tw=1&pmid=28393131 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28393131 #FOAvip English Wikipedia <ref>{{Cite pmid|28393131}}</ref> Controlling T-Cell Activation with Synthetic Dendritic Cells Using the Multivalency Effect #MMPMID28393131 Hammink R; Mandal S; Eggermont LJ; Nooteboom M; Willems PHGM; Tel J; Rowan AE; Figdor CG; Blank KG ACS Omega 2017[Mar]; 2 (3): 937-45 PMID28393131show ga Artificial antigen-presenting cells (aAPCs) have recently gained a lot of attention. They efficiently activate T cells and serve as powerful replacements for dendritic cells in cancer immunotherapy. Focusing on a specific class of polymer-based aAPCs, so-called synthetic dendritic cells (sDCs), we have investigated the importance of multivalent binding on T-cell activation. Using antibody-functionalized sDCs, we have tested the influence of polymer length and antibody density. Increasing the multivalent character of the antibody-functionalized polymer lowered the effective concentration required for T-cell activation. This was evidenced for both early and late stages of activation. The most important effect observed was the significantly prolonged activation of the stimulated T cells, indicating that multivalent sDCs sustain T-cell signaling. Our results highlight the importance of multivalency for the design of aAPCs and will ultimately allow for better mimics of natural dendritic cells that can be used as vaccines in cancer treatment. äControlling T-Cell Activation with Synthetic Dendritic Cells Using the(epmc).pdf DeepDyve Pubget Overpricing