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10.15252/embr.201744000 http://scihub22266oqcxt.onion/10.15252/embr.201744000 C5376977!5376977!28274951     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       EMBO+Rep 2017 ; 18 (4): 549-57 Nephropedia Template TP {{tp|p=28274951|t=2017. TGF?1?induced leucine limitation uncovered by differential ribosome codon reading |pdf=|usr=}}{{28274951}} gab.com Text TGF 1 induced leucine limitation uncovered by differential ribosome codon reading JO: EMBO Rep http://www.kidney.de/pget.php?&tw=1&pmid=28274951 #FOAvip Cancer cells modulate their metabolic networks to support cell proliferation and a higher demand of building blocks. These changes may restrict the availability of certain amino acids for protein synthesis, which can be utilized for cancer therapy. However, little is known about the amino acid demand changes occurring during aggressive and invasive stages of cancer. Recently, we developed diricore, an approach based on ribosome profiling that can uncover amino acid limitations. Here, we applied diricore to a cellular model in which epithelial breast cells respond rapidly to TGF?1, a cytokine essential for cancer progression and metastasis, and uncovered shortage of leucine. Further analyses indicated that TGF?1 treatment of human breast epithelial cells reduces the expression of SLC3A2, a subunit of the leucine transporter, which diminishes leucine uptake and inhibits cell proliferation. Thus, we identified a specific amino acid limitation associated with the TGF?1 response, a vulnerability that might be associated with aggressiveness in cancer. Twit Text FOAVip TGF 1 induced leucine limitation uncovered by differential ribosome codon reading ????EMBO Rep http://www.kidney.de/pget.php?&tw=1&pmid=28274951 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28274951 #FOAvip English Wikipedia <ref>{{Cite pmid|28274951}}</ref> TGF?1?induced leucine limitation uncovered by differential ribosome codon reading #MMPMID28274951 Loayza?Puch F; Rooijers K; Zijlstra J; Moumbeini B; Zaal EA; Oude Vrielink JF; Lopes R; Ugalde AP; Berkers CR; Agami R EMBO Rep 2017[Apr]; 18 (4): 549-57 PMID28274951show ga Cancer cells modulate their metabolic networks to support cell proliferation and a higher demand of building blocks. These changes may restrict the availability of certain amino acids for protein synthesis, which can be utilized for cancer therapy. However, little is known about the amino acid demand changes occurring during aggressive and invasive stages of cancer. Recently, we developed diricore, an approach based on ribosome profiling that can uncover amino acid limitations. Here, we applied diricore to a cellular model in which epithelial breast cells respond rapidly to TGF?1, a cytokine essential for cancer progression and metastasis, and uncovered shortage of leucine. Further analyses indicated that TGF?1 treatment of human breast epithelial cells reduces the expression of SLC3A2, a subunit of the leucine transporter, which diminishes leucine uptake and inhibits cell proliferation. Thus, we identified a specific amino acid limitation associated with the TGF?1 response, a vulnerability that might be associated with aggressiveness in cancer. äTGF?1?induced leucine limitation uncovered by differential ribosome co(epmc).pdf DeepDyve Pubget Overpricing