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10.15252/emmm.201607336 http://scihub22266oqcxt.onion/10.15252/emmm.201607336 C5376759!5376759!28202493     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       EMBO+Mol+Med 2017 ; 9 (4): 430-47 Nephropedia Template TP {{tp|p=28202493|t=2017. A Klebsiella pneumoniae antibiotic resistance mechanism that subdues host defences and promotes virulence |pdf=|usr=}}{{28202493}} gab.com Text A Klebsiella pneumoniae antibiotic resistance mechanism that subdues host defences and promotes virulence JO: EMBO Mol Med http://www.kidney.de/pget.php?&tw=1&pmid=28202493 #FOAvip Klebsiella pneumoniae is an important cause of multidrug?resistant infections worldwide. Recent studies highlight the emergence of multidrug?resistant K. pneumoniae strains which show resistance to colistin, a last?line antibiotic, arising from mutational inactivation of the mgrB regulatory gene. However, the precise molecular resistance mechanisms of mgrB?associated colistin resistance and its impact on virulence remain unclear. Here, we constructed an mgrB gene K. pneumoniae mutant and performed characterisation of its lipid A structure, polymyxin and antimicrobial peptide resistance, virulence and inflammatory responses upon infection. Our data reveal that mgrB mutation induces PhoPQ?governed lipid A remodelling which confers not only resistance to polymyxins, but also enhances K. pneumoniae virulence by decreasing antimicrobial peptide susceptibility and attenuating early host defence response activation. Overall, our findings have important implications for patient management and antimicrobial stewardship, while also stressing antibiotic resistance development is not inexorably linked with subdued bacterial fitness and virulence. Twit Text FOAVip A Klebsiella pneumoniae antibiotic resistance mechanism that subdues host defences and promotes virulence ????EMBO Mol Med http://www.kidney.de/pget.php?&tw=1&pmid=28202493 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28202493 #FOAvip English Wikipedia <ref>{{Cite pmid|28202493}}</ref> A Klebsiella pneumoniae antibiotic resistance mechanism that subdues host defences and promotes virulence #MMPMID28202493 Kidd TJ; Mills G; Sá?Pessoa J; Dumigan A; Frank CG; Insua JL; Ingram R; Hobley L; Bengoechea JA EMBO Mol Med 2017[Apr]; 9 (4): 430-47 PMID28202493show ga Klebsiella pneumoniae is an important cause of multidrug?resistant infections worldwide. Recent studies highlight the emergence of multidrug?resistant K. pneumoniae strains which show resistance to colistin, a last?line antibiotic, arising from mutational inactivation of the mgrB regulatory gene. However, the precise molecular resistance mechanisms of mgrB?associated colistin resistance and its impact on virulence remain unclear. Here, we constructed an mgrB gene K. pneumoniae mutant and performed characterisation of its lipid A structure, polymyxin and antimicrobial peptide resistance, virulence and inflammatory responses upon infection. Our data reveal that mgrB mutation induces PhoPQ?governed lipid A remodelling which confers not only resistance to polymyxins, but also enhances K. pneumoniae virulence by decreasing antimicrobial peptide susceptibility and attenuating early host defence response activation. Overall, our findings have important implications for patient management and antimicrobial stewardship, while also stressing antibiotic resistance development is not inexorably linked with subdued bacterial fitness and virulence. äA Klebsiella pneumoniae antibiotic resistance mechanism that subdues h(epmc).pdf DeepDyve Pubget Overpricing