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10.15252/emmm.201606660 http://scihub22266oqcxt.onion/10.15252/emmm.201606660 C5376749!5376749!28264936     free     free     free Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 261.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 261.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 261.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       EMBO+Mol+Med 2017 ; 9 (4): 498-507 Nephropedia Template TP {{tp|p=28264936|t=2017. Deletion of ribosomal protein genes is a common vulnerability in human cancer, especially in concert with TP53 mutations |pdf=|usr=}}{{28264936}} gab.com Text Deletion of ribosomal protein genes is a common vulnerability in human cancer, especially in concert with TP53 mutations JO: EMBO Mol Med http://www.kidney.de/pget.php?&tw=1&pmid=28264936 #FOAvip Heterozygous inactivating mutations in ribosomal protein genes (RPGs) are associated with hematopoietic and developmental abnormalities, activation of p53, and altered risk of cancer in humans and model organisms. Here we performed a large?scale analysis of cancer genome data to examine the frequency and selective pressure of RPG lesions across human cancers. We found that hemizygous RPG deletions are common, occurring in about 43% of 10,744 cancer specimens and cell lines. Consistent with p53?dependent negative selection, such lesions are underrepresented in TP53?intact tumors (P ? 10?10), and shRNA?mediated knockdown of RPGs activated p53 in TP53?wild?type cells. In contrast, we did not see negative selection of RPG deletions in TP53?mutant tumors. RPGs are conserved with respect to homozygous deletions, and shRNA screening data from 174 cell lines demonstrate that further suppression of hemizygously deleted RPGs inhibits cell growth. Our results establish RPG haploinsufficiency as a strikingly common vulnerability of human cancers that associates with TP53 mutations and could be targetable therapeutically. Twit Text FOAVip Deletion of ribosomal protein genes is a common vulnerability in human cancer, especially in concert with TP53 mutations ????EMBO Mol Med http://www.kidney.de/pget.php?&tw=1&pmid=28264936 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28264936 #FOAvip English Wikipedia <ref>{{Cite pmid|28264936}}</ref> Deletion of ribosomal protein genes is a common vulnerability in human cancer, especially in concert with TP53 mutations #MMPMID28264936 Ajore R; Raiser D; McConkey M; Jöud M; Boidol B; Mar B; Saksena G; Weinstock DM; Armstrong S; Ellis SR; Ebert BL; Nilsson B EMBO Mol Med 2017[Apr]; 9 (4): 498-507 PMID28264936show ga Heterozygous inactivating mutations in ribosomal protein genes (RPGs) are associated with hematopoietic and developmental abnormalities, activation of p53, and altered risk of cancer in humans and model organisms. Here we performed a large?scale analysis of cancer genome data to examine the frequency and selective pressure of RPG lesions across human cancers. We found that hemizygous RPG deletions are common, occurring in about 43% of 10,744 cancer specimens and cell lines. Consistent with p53?dependent negative selection, such lesions are underrepresented in TP53?intact tumors (P ? 10?10), and shRNA?mediated knockdown of RPGs activated p53 in TP53?wild?type cells. In contrast, we did not see negative selection of RPG deletions in TP53?mutant tumors. RPGs are conserved with respect to homozygous deletions, and shRNA screening data from 174 cell lines demonstrate that further suppression of hemizygously deleted RPGs inhibits cell growth. Our results establish RPG haploinsufficiency as a strikingly common vulnerability of human cancers that associates with TP53 mutations and could be targetable therapeutically. äDeletion of ribosomal protein genes is a common vulnerability in human(epmc).pdf DeepDyve Pubget Overpricing