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10.1186/s12916-017-0835-3 http://scihub22266oqcxt.onion/10.1186/s12916-017-0835-3 C5376681!5376681!28366170     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 298.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       BMC+Med 2017 ; 15 (ä): ä Nephropedia Template TP {{tp|p=28366170|t=2017. Treatment duration of febrile urinary tract infection: a pragmatic randomized, double-blind, placebo-controlled non-inferiority trial in men and women |pdf=|usr=}}{{28366170}} gab.com Text Treatment duration of febrile urinary tract infection: a pragmatic randomized, double-blind, placebo-controlled non-inferiority trial in men and women JO: BMC Med http://www.kidney.de/pget.php?&tw=1&pmid=28366170 #FOAvip Background: In adults with febrile urinary tract infection (fUTI), data on optimal treatment duration in patients other than non-pregnant women without comorbidities are lacking. Methods: A randomized placebo-controlled, double-blind, non-inferiority trial among 35 primary care centers and 7 emergency departments of regional hospitals in the Netherlands. Women and men aged???18 years with a diagnosis of fUTI were randomly assigned to receive antibiotic treatment for 7 or 14 days (the second week being ciprofloxacin 500 mg or placebo orally twice daily). Patients indicated to receive antimicrobial treatment for at least 14 days were excluded from randomization.The primary endpoint was the clinical cure rate through the 10- to 18-day post-treatment visit with preset subgroup analysis including sex. Secondary endpoints were bacteriologic cure rate at 10?18 days post-treatment and clinical cure at 70?84 days post-treatment. Results: Of 357 patients included, 200 were eligible for randomization; 97 patients were randomly assigned to 7 days and 103 patients to 14 days of treatment. Overall, short-term clinical cure occurred in 85 (90%) patients treated for 7 days and in 94 (95%) of those treated for 14 days (difference ?4.5%; 90% CI, ?10.7 to 1.7; Pnon-inferiority?=?0.072, non-inferiority not confirmed). In women, clinical cure was 94% and 93% in those treated for 7 and 14 days, respectively (difference 0.9; 90% CI, ?6.9 to 8.7, Pnon-inferiority?=?0.011, non-inferiority confirmed) and, in men, this was 86% versus 98% (difference ?11.2; 90% CI ?20.6 to ?1.8, Psuperiority?=?0.025, inferiority confirmed).The bacteriologic cure rate was 93% versus 97% (difference ?4.3%; 90% CI, ?9.7 to 1.2, Pnon-inferiority?=?0.041) and the long-term clinical cure rate was 92% versus 91% (difference 1.6%; 90% CI, ?5.3 to 8.4; Pnon-inferiority?=?0.005) for 7 days versus 14 days of treatment, respectively. In the subgroups of men and women, long-term clinical cure rates met the criteria for non-inferiority, indicating there was no difference in the need for antibiotic retreatment for UTI during 70?84 days follow-up post-treatment. Conclusions: Women with fUTI can be treated successfully with antibiotics for 7 days. In men, 7 days of antibiotic treatment for fUTI is inferior to 14 days during short-term follow-up but it is non-inferior when looking at longer follow-up. Trial registration: The study was registered at ClinicalTrials.gov [NCT00809913; December 16, 2008] and trialregister.nl [NTR1583; December 19, 2008]. Electronic supplementary material: The online version of this article (doi:10.1186/s12916-017-0835-3) contains supplementary material, which is available to authorized users. Twit Text FOAVip Treatment duration of febrile urinary tract infection: a pragmatic randomized, double-blind, placebo-controlled non-inferiority trial in men and women ????BMC Med http://www.kidney.de/pget.php?&tw=1&pmid=28366170 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28366170 #FOAvip English Wikipedia <ref>{{Cite pmid|28366170}}</ref> Treatment duration of febrile urinary tract infection: a pragmatic randomized, double-blind, placebo-controlled non-inferiority trial in men and women #MMPMID28366170 van Nieuwkoop C; van der Starre WE; Stalenhoef JE; van Aartrijk AM; van der Reijden TJK; Vollaard AM; Delfos NM; van ?t Wout JW; Blom JW; Spelt IC; Leyten EMS; Koster T; Ablij HC; van der Beek MT; Knol MJ; van Dissel JT BMC Med 2017[]; 15 (ä): ä PMID28366170show ga Background: In adults with febrile urinary tract infection (fUTI), data on optimal treatment duration in patients other than non-pregnant women without comorbidities are lacking. Methods: A randomized placebo-controlled, double-blind, non-inferiority trial among 35 primary care centers and 7 emergency departments of regional hospitals in the Netherlands. Women and men aged???18 years with a diagnosis of fUTI were randomly assigned to receive antibiotic treatment for 7 or 14 days (the second week being ciprofloxacin 500 mg or placebo orally twice daily). Patients indicated to receive antimicrobial treatment for at least 14 days were excluded from randomization.The primary endpoint was the clinical cure rate through the 10- to 18-day post-treatment visit with preset subgroup analysis including sex. Secondary endpoints were bacteriologic cure rate at 10?18 days post-treatment and clinical cure at 70?84 days post-treatment. Results: Of 357 patients included, 200 were eligible for randomization; 97 patients were randomly assigned to 7 days and 103 patients to 14 days of treatment. Overall, short-term clinical cure occurred in 85 (90%) patients treated for 7 days and in 94 (95%) of those treated for 14 days (difference ?4.5%; 90% CI, ?10.7 to 1.7; Pnon-inferiority?=?0.072, non-inferiority not confirmed). In women, clinical cure was 94% and 93% in those treated for 7 and 14 days, respectively (difference 0.9; 90% CI, ?6.9 to 8.7, Pnon-inferiority?=?0.011, non-inferiority confirmed) and, in men, this was 86% versus 98% (difference ?11.2; 90% CI ?20.6 to ?1.8, Psuperiority?=?0.025, inferiority confirmed).The bacteriologic cure rate was 93% versus 97% (difference ?4.3%; 90% CI, ?9.7 to 1.2, Pnon-inferiority?=?0.041) and the long-term clinical cure rate was 92% versus 91% (difference 1.6%; 90% CI, ?5.3 to 8.4; Pnon-inferiority?=?0.005) for 7 days versus 14 days of treatment, respectively. In the subgroups of men and women, long-term clinical cure rates met the criteria for non-inferiority, indicating there was no difference in the need for antibiotic retreatment for UTI during 70?84 days follow-up post-treatment. Conclusions: Women with fUTI can be treated successfully with antibiotics for 7 days. In men, 7 days of antibiotic treatment for fUTI is inferior to 14 days during short-term follow-up but it is non-inferior when looking at longer follow-up. Trial registration: The study was registered at ClinicalTrials.gov [NCT00809913; December 16, 2008] and trialregister.nl [NTR1583; December 19, 2008]. Electronic supplementary material: The online version of this article (doi:10.1186/s12916-017-0835-3) contains supplementary material, which is available to authorized users. äTreatment duration of febrile urinary tract infection: a pragmatic ran(epmc).pdf DeepDyve Pubget Overpricing