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10.1128/MCB.00424-16 http://scihub22266oqcxt.onion/10.1128/MCB.00424-16 C5376635!5376635 !28137909     free     free     free Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 261.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 261.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28137909 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Mol+Cell+Biol 2017 ; 37 (8 ): ä Nephropedia Template TP {{tp|p=28137909 |t=2017. NDR1-Dependent Regulation of Kindlin-3 Controls High-Affinity LFA-1 Binding and Immune Synapse Organization |pdf=|usr=}}{{28137909 }} gab.com Text NDR1-Dependent Regulation of Kindlin-3 Controls High-Affinity LFA-1 Binding and Immune Synapse Organization JO: Mol Cell Biol http://www.kidney.de/pget.php?&tw=1&pmid=28137909 #FOAvip Antigen-specific adhesion between T cells and antigen-presenting cells (APC) during the formation of the immunological synapse (IS) is mediated by LFA-1 and ICAM-1. Here, LFA-1-ICAM-1 interactions were measured at the single-molecule level on supported lipid bilayers. High-affinity binding was detected at low frequencies in the inner peripheral supramolecular activation cluster (SMAC) zone that contained high levels of activated Rap1 and kindlin-3. Rap1 was essential for T cell attachment, whereas deficiencies of ste20-like kinases, Mst1/Mst2, diminished high-affinity binding and abrogated central SMAC (cSMAC) formation with mislocalized kindlin-3 and vesicle transport regulators involved in T cell receptor recycling/releasing machineries, resulting in impaired T cell-APC interactions. We found that NDR1 kinase, activated by the Rap1 signaling cascade through RAPL and Mst1/Mst2, associated with and recruited kindlin-3 to the IS, which was required for high-affinity LFA-1/ICAM-1 binding and cSMAC formation. Our findings reveal crucial roles for Rap1 signaling via NDR1 for recruitment of kindlin-3 and IS organization. Twit Text FOAVip NDR1-Dependent Regulation of Kindlin-3 Controls High-Affinity LFA-1 Binding and Immune Synapse Organization ????Mol Cell Biol http://www.kidney.de/pget.php?&tw=1&pmid=28137909 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28137909 #FOAvip English Wikipedia <ref>{{Cite pmid|28137909 }}</ref> NDR1-Dependent Regulation of Kindlin-3 Controls High-Affinity LFA-1 Binding and Immune Synapse Organization #MMPMID28137909 Kondo N ; Ueda Y ; Kita T ; Ozawa M ; Tomiyama T ; Yasuda K ; Lim DS ; Kinashi T Mol Cell Biol 2017[Apr]; 37 (8 ): ä PMID28137909 show ga Antigen-specific adhesion between T cells and antigen-presenting cells (APC) during the formation of the immunological synapse (IS) is mediated by LFA-1 and ICAM-1. Here, LFA-1-ICAM-1 interactions were measured at the single-molecule level on supported lipid bilayers. High-affinity binding was detected at low frequencies in the inner peripheral supramolecular activation cluster (SMAC) zone that contained high levels of activated Rap1 and kindlin-3. Rap1 was essential for T cell attachment, whereas deficiencies of ste20-like kinases, Mst1/Mst2, diminished high-affinity binding and abrogated central SMAC (cSMAC) formation with mislocalized kindlin-3 and vesicle transport regulators involved in T cell receptor recycling/releasing machineries, resulting in impaired T cell-APC interactions. We found that NDR1 kinase, activated by the Rap1 signaling cascade through RAPL and Mst1/Mst2, associated with and recruited kindlin-3 to the IS, which was required for high-affinity LFA-1/ICAM-1 binding and cSMAC formation. Our findings reveal crucial roles for Rap1 signaling via NDR1 for recruitment of kindlin-3 and IS organization. |Animals [MESH] |Cell Cycle Proteins/*metabolism [MESH] |Cytoskeletal Proteins/*metabolism [MESH] |HEK293 Cells [MESH] |Hepatocyte Growth Factor/metabolism [MESH] |Humans [MESH] |Immunological Synapses/*metabolism [MESH] |Intercellular Adhesion Molecule-1/metabolism [MESH] |Intracellular Signaling Peptides and Proteins/*metabolism [MESH] |Lymphocyte Function-Associated Antigen-1/*metabolism [MESH] |Mice, Inbred C57BL [MESH] |Protein Binding [MESH] |Protein Serine-Threonine Kinases/metabolism [MESH] |Proto-Oncogene Proteins/metabolism [MESH] |Serine-Threonine Kinase 3 [MESH] |Signal Transduction [MESH] |Single Molecule Imaging [MESH] |Transport Vesicles/metabolism [MESH]NDR1-Dependent Regulation of Kindlin-3 Controls High-Affinity LFA-1 Bi(epmc).pdf DeepDyve Pubget Overpricing