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10.1038/ncb3491 http://scihub22266oqcxt.onion/10.1038/ncb3491 C5376241!5376241!28319092     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Cell+Biol 2017 ; 19 (4): 341-51 Nephropedia Template TP {{tp|p=28319092|t=2017. The TDH-GCN5L1-Fbxo15-KBP axis limits mitochondrial biogenesis in mouse embryonic stem cells |pdf=|usr=}}{{28319092}} gab.com Text The TDH-GCN5L1-Fbxo15-KBP axis limits mitochondrial biogenesis in mouse embryonic stem cells JO: Nat Cell Biol http://www.kidney.de/pget.php?&tw=1&pmid=28319092 #FOAvip Self-renewing naïve mouse embryonic stem cells (mESCs) contain few mitochondria, which increase in number and volume at the onset of differentiation. KBP (encoded by Kif1bp) is an interactor of the mitochondrial-associated kinesin Kif1B?. We found that TDH, responsible for mitochondrial production of acetylCoA in mESCs, and the acetyl-transferase GCN5L1 cooperate to acetylate Lys501 in KBP, allowing its recognition by and degradation via Fbxo15, an F-box protein transcriptionally controlled by the pluripotency core factors and repressed upon differentiation. Defects in KBP degradation in mESCs result in unscheduled increase in mitochondrial biogenesis, enhanced respiration and ROS production, and inhibition of cell proliferation. Silencing of Kif1B? reverts the aberrant increase in mitochondria induced by KBP stabilization. Notably, upon differentiation, Kif1bp?/? mESCs display impaired expansion of the mitochondrial mass and form smaller embryoid bodies. Thus, KBP proteolysis limits the accumulation of mitochondria in mESCs to preserve their optimal fitness, whereas KBP accumulation promotes mitochondrial biogenesis in differentiating cells. Twit Text FOAVip The TDH-GCN5L1-Fbxo15-KBP axis limits mitochondrial biogenesis in mouse embryonic stem cells ????Nat Cell Biol http://www.kidney.de/pget.php?&tw=1&pmid=28319092 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28319092 #FOAvip English Wikipedia <ref>{{Cite pmid|28319092}}</ref> The TDH-GCN5L1-Fbxo15-KBP axis limits mitochondrial biogenesis in mouse embryonic stem cells #MMPMID28319092 Donato V; Bonora M; Simoneschi D; Sartini D; Kudo Y; Saraf A; Florens L; Washburn MP; Stadtfeld M; Pinton P; Pagano M Nat Cell Biol 2017[Apr]; 19 (4): 341-51 PMID28319092show ga Self-renewing naïve mouse embryonic stem cells (mESCs) contain few mitochondria, which increase in number and volume at the onset of differentiation. KBP (encoded by Kif1bp) is an interactor of the mitochondrial-associated kinesin Kif1B?. We found that TDH, responsible for mitochondrial production of acetylCoA in mESCs, and the acetyl-transferase GCN5L1 cooperate to acetylate Lys501 in KBP, allowing its recognition by and degradation via Fbxo15, an F-box protein transcriptionally controlled by the pluripotency core factors and repressed upon differentiation. Defects in KBP degradation in mESCs result in unscheduled increase in mitochondrial biogenesis, enhanced respiration and ROS production, and inhibition of cell proliferation. Silencing of Kif1B? reverts the aberrant increase in mitochondria induced by KBP stabilization. Notably, upon differentiation, Kif1bp?/? mESCs display impaired expansion of the mitochondrial mass and form smaller embryoid bodies. Thus, KBP proteolysis limits the accumulation of mitochondria in mESCs to preserve their optimal fitness, whereas KBP accumulation promotes mitochondrial biogenesis in differentiating cells. äThe TDH-GCN5L1-Fbxo15-KBP axis limits mitochondrial biogenesis in mous(epmc).pdf DeepDyve Pubget Overpricing