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http://scihub22266oqcxt.onion/ C5376030!5376030!28386365     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Am+J+Transl+Res 2017 ; 9 (3): 1402-9 Nephropedia Template TP {{tp|p=28386365|t=2017. Calpain 1 regulates TGF-?1-induced epithelial-mesenchymal transition in human lung epithelial cells via PI3K/Akt signaling pathway |pdf=|usr=}}{{28386365}} gab.com Text Calpain 1 regulates TGF- 1-induced epithelial-mesenchymal transition in human lung epithelial cells via PI3K/Akt signaling pathway JO: Am J Transl Res http://www.kidney.de/pget.php?&tw=1&pmid=28386365 #FOAvip Cell proliferation, transformation, and epithelial-mesenchymal transition (EMT) are key processes involved in the development of idiopathic pulmonary fibrosis (IPF). This study investigated the regulatory factors and signaling pathways that mediate EMT in the human type II alveolar epithelial A549 cell line. A549 cells were cultured in RPMI-1640 medium and allocated to the following four groups: blank control group or treated with transforming growth factor-?1 (TGF-?1), TGF-?1 + PD 150606 (a calpain 1 inhibitor), or PD 150606. We examined E-cadherin (E-cad), ?-smooth muscle actin (?-SMA), and calpain 1 mRNA transcript and protein expression levels in these four groups by performing RT-PCR and western blot analyses. The results indicated that TGF-?1 treatment significantly downregulated E-cad and upregulated ?-SMA expression compared with that of the blank control group (P<0.05). TGF-?1 also enhanced calpain 1 expression compared with that of the blank control group (P<0.05). By contrast, treatment with the calpain 1 inhibitor PD 150606 increased E-cad expression and decreased ?-SMA expression. Furthermore, PD 150606 treatment antagonized TGF-?1-mediated increase in Akt/phospho-Akt in A549 epithelial cells. However, TGF-?1-induced ETM was not correlated with the ERK and JNK signaling pathways. These combined results indicate that calpain 1 could regulate EMT in TGF-?1-treated A549 epithelial cells via the PI3K/Akt signaling pathway. Twit Text FOAVip Calpain 1 regulates TGF- 1-induced epithelial-mesenchymal transition in human lung epithelial cells via PI3K/Akt signaling pathway ????Am J Transl Res http://www.kidney.de/pget.php?&tw=1&pmid=28386365 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28386365 #FOAvip English Wikipedia <ref>{{Cite pmid|28386365}}</ref> Calpain 1 regulates TGF-?1-induced epithelial-mesenchymal transition in human lung epithelial cells via PI3K/Akt signaling pathway #MMPMID28386365 Tan WJ; Tan QY; Wang T; Lian M; Zhang L; Cheng ZS Am J Transl Res 2017[]; 9 (3): 1402-9 PMID28386365show ga Cell proliferation, transformation, and epithelial-mesenchymal transition (EMT) are key processes involved in the development of idiopathic pulmonary fibrosis (IPF). This study investigated the regulatory factors and signaling pathways that mediate EMT in the human type II alveolar epithelial A549 cell line. A549 cells were cultured in RPMI-1640 medium and allocated to the following four groups: blank control group or treated with transforming growth factor-?1 (TGF-?1), TGF-?1 + PD 150606 (a calpain 1 inhibitor), or PD 150606. We examined E-cadherin (E-cad), ?-smooth muscle actin (?-SMA), and calpain 1 mRNA transcript and protein expression levels in these four groups by performing RT-PCR and western blot analyses. The results indicated that TGF-?1 treatment significantly downregulated E-cad and upregulated ?-SMA expression compared with that of the blank control group (P<0.05). TGF-?1 also enhanced calpain 1 expression compared with that of the blank control group (P<0.05). By contrast, treatment with the calpain 1 inhibitor PD 150606 increased E-cad expression and decreased ?-SMA expression. Furthermore, PD 150606 treatment antagonized TGF-?1-mediated increase in Akt/phospho-Akt in A549 epithelial cells. However, TGF-?1-induced ETM was not correlated with the ERK and JNK signaling pathways. These combined results indicate that calpain 1 could regulate EMT in TGF-?1-treated A549 epithelial cells via the PI3K/Akt signaling pathway. äCalpain 1 regulates TGF-?1-induced epithelial-mesenchymal transition i(epmc).pdf DeepDyve Pubget Overpricing