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http://scihub22266oqcxt.onion/ C5375998!5375998!28386333     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Am+J+Transl+Res 2017 ; 9 (3): 1058-66 Nephropedia Template TP {{tp|p=28386333|t=2017. MicroRNA-150 regulates glycolysis by targeting von Hippel-Lindau in glioma cells |pdf=|usr=}}{{28386333}} gab.com Text MicroRNA-150 regulates glycolysis by targeting von Hippel-Lindau in glioma cells JO: Am J Transl Res http://www.kidney.de/pget.php?&tw=1&pmid=28386333 #FOAvip Warburg effect, characterized by enhanced glycolysis and lactate production, even under aerobic conditions, is one of the hallmarks of cancer cells. However, the mechanism underlying this phenomenon remains poorly understood. Previous studies have shown that microRNA-150 (miR-150) is significantly up-regulated in various malignancies and represents a putative onco-miRNA in human cancers. In the present study, we aim to investigate the functional significance and molecular target of miR-150 in glioma. As a result, von Hippel-Lindau (VHL), which is a specific E3 ligase for hypoxia inducible factor 1 (HIF1?), was identified as a novel target of miR-150. Consistently, cells overexpressing miR-150 exhibited a metabolic shift, including enhanced glucose uptake and lactate production, which led to a rapid growth of glioma cells. Therefore, our results suggest that miR-150 modulates the Warburg effect in glioma via VHL/HIF1? and might provide a novel option for future treatments for glioma. Twit Text FOAVip MicroRNA-150 regulates glycolysis by targeting von Hippel-Lindau in glioma cells ????Am J Transl Res http://www.kidney.de/pget.php?&tw=1&pmid=28386333 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28386333 #FOAvip English Wikipedia <ref>{{Cite pmid|28386333}}</ref> MicroRNA-150 regulates glycolysis by targeting von Hippel-Lindau in glioma cells #MMPMID28386333 Li SJ; Liu HL; Tang SL; Li XJ; Wang XY Am J Transl Res 2017[]; 9 (3): 1058-66 PMID28386333show ga Warburg effect, characterized by enhanced glycolysis and lactate production, even under aerobic conditions, is one of the hallmarks of cancer cells. However, the mechanism underlying this phenomenon remains poorly understood. Previous studies have shown that microRNA-150 (miR-150) is significantly up-regulated in various malignancies and represents a putative onco-miRNA in human cancers. In the present study, we aim to investigate the functional significance and molecular target of miR-150 in glioma. As a result, von Hippel-Lindau (VHL), which is a specific E3 ligase for hypoxia inducible factor 1 (HIF1?), was identified as a novel target of miR-150. Consistently, cells overexpressing miR-150 exhibited a metabolic shift, including enhanced glucose uptake and lactate production, which led to a rapid growth of glioma cells. Therefore, our results suggest that miR-150 modulates the Warburg effect in glioma via VHL/HIF1? and might provide a novel option for future treatments for glioma. äMicroRNA-150 regulates glycolysis by targeting von Hippel-Lindau in gl(epmc).pdf DeepDyve Pubget Overpricing