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http://scihub22266oqcxt.onion/ C5375980!5375980!28386315     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Am+J+Transl+Res 2017 ; 9 (3): 823-9 Nephropedia Template TP {{tp|p=28386315|t=2017. Protective benefits of AMP-activated protein kinase in hepatic ischemia-reperfusion injury |pdf=|usr=}}{{28386315}} gab.com Text Protective benefits of AMP-activated protein kinase in hepatic ischemia-reperfusion injury JO: Am J Transl Res http://www.kidney.de/pget.php?&tw=1&pmid=28386315 #FOAvip Hepatic ischemia-reperfusion injury (HIRI) is a major cause of hepatic failure and death after liver trauma, haemorrhagic shock, resection surgery and liver transplantation. AMP-activated protein kinase (AMPK) is an energy sensitive kinase that plays crucial roles in the regulation of metabolic homeostasis. In HIRI, ischemia induces the decline of ATP and the increased ratio of AMP/ATP, which promotes the phosphorylation and activation of AMPK. Three AMPK kinases, liver kinase B1 (LKB1), Ca2+/calmodulin-depedent protein kinase kinase ? (CaMKK?) and TGF-?-activated kinase-1 (TAK1), are main upstream kinases for the phosphorylation of AMPK. In addition to the changed AMP/ATP ratio, the activated CaMKK? by increased intracelluar Ca2+ and the overproduction of reactive oxygen species (ROS) are also involved in the activation of AMPK during HIRI. The activated AMPK might provide protective benefits in HIRI via prevention of energy decline, inhibition of inflammatory response, suppression of hepatocyte apoptosis and attenuation of oxidative stress. Thus, AMPK might become a novel target for the pharmacological intervention of HIRI. Twit Text FOAVip Protective benefits of AMP-activated protein kinase in hepatic ischemia-reperfusion injury ????Am J Transl Res http://www.kidney.de/pget.php?&tw=1&pmid=28386315 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28386315 #FOAvip English Wikipedia <ref>{{Cite pmid|28386315}}</ref> Protective benefits of AMP-activated protein kinase in hepatic ischemia-reperfusion injury #MMPMID28386315 Zhang M; Yang D; Gong X; Ge P; Dai J; Lin L; Zhang L Am J Transl Res 2017[]; 9 (3): 823-9 PMID28386315show ga Hepatic ischemia-reperfusion injury (HIRI) is a major cause of hepatic failure and death after liver trauma, haemorrhagic shock, resection surgery and liver transplantation. AMP-activated protein kinase (AMPK) is an energy sensitive kinase that plays crucial roles in the regulation of metabolic homeostasis. In HIRI, ischemia induces the decline of ATP and the increased ratio of AMP/ATP, which promotes the phosphorylation and activation of AMPK. Three AMPK kinases, liver kinase B1 (LKB1), Ca2+/calmodulin-depedent protein kinase kinase ? (CaMKK?) and TGF-?-activated kinase-1 (TAK1), are main upstream kinases for the phosphorylation of AMPK. In addition to the changed AMP/ATP ratio, the activated CaMKK? by increased intracelluar Ca2+ and the overproduction of reactive oxygen species (ROS) are also involved in the activation of AMPK during HIRI. The activated AMPK might provide protective benefits in HIRI via prevention of energy decline, inhibition of inflammatory response, suppression of hepatocyte apoptosis and attenuation of oxidative stress. Thus, AMPK might become a novel target for the pharmacological intervention of HIRI. äProtective benefits of AMP-activated protein kinase in hepatic ischemi(epmc).pdf DeepDyve Pubget Overpricing