Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.3892/br.2017.875 http://scihub22266oqcxt.onion/10.3892/br.2017.875 C5374932!5374932!28413644     free     free     free Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Biomed+Rep 2017 ; 6 (4): 449-54 Nephropedia Template TP {{tp|p=28413644|t=2017. Reduction in miRNA-125b-5p levels is associated with obstructive renal injury |pdf=|usr=}}{{28413644}} gab.com Text Reduction in miRNA-125b-5p levels is associated with obstructive renal injury JO: Biomed Rep http://www.kidney.de/pget.php?&tw=1&pmid=28413644 #FOAvip Obstructive renal injury is a common disease that leads to progressive glomerulosclerosis, tubulointerstitial fibrosis and loss of renal function. MicroRNAs (miRNAs/miRs) are small non-coding molecules that may be involved in the progression of many renal diseases. The aim of the present study was to investigate the roles of miRNAs, including miR-125b, miR-326 and miR-324p, in obstructive renal injury. Blood samples were collected from 91 patients with ureteral obstruction and 76 controls to examine renal function. In addition, the levels of miR-125b, miR-326 and miR-324p in patients with ureteral obstruction and controls were determined by the reverse transcription-quantitative polymerase chain reaction. Furthermore, the relationship between miRNA levels and renal function was evaluated by the Mann-Whitney U test. Upregulated levels of serum creatinine (SCr) in patients with ureteral obstruction were observed, identifying the injury of renal function. Although the expression levels of miR-324-5p [1.003 (0.391?2.279) vs. 0.934 (0.579?1.539), P=0.300] and miR-326 [0.840 (0.180?2.020) vs. 0.949 (0.507?1.702), P=0.050] presented no significant difference, the levels of miR-125b-5p [0.755 (0.210?2.110) vs. 0.960 (0.390?1.770), P=0.002] in patients with ureteral obstruction were significantly lower than those in controls. These results indicated that there is a stronger correlation of miR-125b-5p with the occurrence of ureteral obstruction, especially for the female (P=0.0171) and elderly (P=0.0142). Furthermore, the levels of miR-125b-5p (r=?0.175, P=0.038) were closely associated with the serum levels of SCr, suggesting a key role of miR-125b-5p in renal dysfunction. Thus, these findings suggested that miR-125b-5p in patients with ureteral obstruction correlated with renal function, and may be a potential biomarker for obstructive renal injury. Twit Text FOAVip Reduction in miRNA-125b-5p levels is associated with obstructive renal injury ????Biomed Rep http://www.kidney.de/pget.php?&tw=1&pmid=28413644 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28413644 #FOAvip English Wikipedia <ref>{{Cite pmid|28413644}}</ref> Reduction in miRNA-125b-5p levels is associated with obstructive renal injury #MMPMID28413644 Wang S; Wu L; Du L; Lu H; Chen B; Bai Y Biomed Rep 2017[Apr]; 6 (4): 449-54 PMID28413644show ga Obstructive renal injury is a common disease that leads to progressive glomerulosclerosis, tubulointerstitial fibrosis and loss of renal function. MicroRNAs (miRNAs/miRs) are small non-coding molecules that may be involved in the progression of many renal diseases. The aim of the present study was to investigate the roles of miRNAs, including miR-125b, miR-326 and miR-324p, in obstructive renal injury. Blood samples were collected from 91 patients with ureteral obstruction and 76 controls to examine renal function. In addition, the levels of miR-125b, miR-326 and miR-324p in patients with ureteral obstruction and controls were determined by the reverse transcription-quantitative polymerase chain reaction. Furthermore, the relationship between miRNA levels and renal function was evaluated by the Mann-Whitney U test. Upregulated levels of serum creatinine (SCr) in patients with ureteral obstruction were observed, identifying the injury of renal function. Although the expression levels of miR-324-5p [1.003 (0.391?2.279) vs. 0.934 (0.579?1.539), P=0.300] and miR-326 [0.840 (0.180?2.020) vs. 0.949 (0.507?1.702), P=0.050] presented no significant difference, the levels of miR-125b-5p [0.755 (0.210?2.110) vs. 0.960 (0.390?1.770), P=0.002] in patients with ureteral obstruction were significantly lower than those in controls. These results indicated that there is a stronger correlation of miR-125b-5p with the occurrence of ureteral obstruction, especially for the female (P=0.0171) and elderly (P=0.0142). Furthermore, the levels of miR-125b-5p (r=?0.175, P=0.038) were closely associated with the serum levels of SCr, suggesting a key role of miR-125b-5p in renal dysfunction. Thus, these findings suggested that miR-125b-5p in patients with ureteral obstruction correlated with renal function, and may be a potential biomarker for obstructive renal injury. äReduction in miRNA-125b-5p levels is associated with obstructive renal(epmc).pdf DeepDyve Pubget Overpricing