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10.1186/s13019-017-0582-8 http://scihub22266oqcxt.onion/10.1186/s13019-017-0582-8 C5374690!5374690!28359339     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Cardiothorac+Surg 2017 ; 12 (ä): ä Nephropedia Template TP {{tp|p=28359339|t=2017. High dose statin prophylaxis in cardiopulmonary bypass related surgery: clinical utility |pdf=|usr=}}{{28359339}} gab.com Text High dose statin prophylaxis in cardiopulmonary bypass related surgery: clinical utility JO: J Cardiothorac Surg http://www.kidney.de/pget.php?&tw=1&pmid=28359339 #FOAvip Background: Previous studies from our group demonstrated the anti-inflammatory properties of statins on cardiopulmonary bypass (CPB), through inhibition of neutrophil transendothelial migration. We sought to determine the utility of preoperative statin on patients undergoing cardiac surgery, to investigate any moderating effects on the systemic inflammatory response (SIRS) with CPB, and to evaluate any clinical impact on our patients. Methods: This is a prospective, randomised controlled trial with national regulatory body approval. Eligible patients were already on oral statin therapy. They were then randomly assigned to either investigation arm (n?=?15, atorvastatin 80 mg for 2 weeks before surgery) or control arm (n?=?15, no change to current statin therapy). Blood and urine samples were collected at 3 timepoints. Postoperative clinical measures were documented. Results: Patients in the investigation arm have significantly lower troponin level (p?=?0.016), and lower level of urine neutrophil gelatinase-associated lipocalin (NGAL; p?=?0.002); thus demonstrating a lesser degree of cardiac and renal injury in these patients. Higher level of Interleukin-8 (IL-8) at baseline (p?=?0.036) and 4 h post cross-clamp removal (p?=?0.035) in the investiation arm. A similar trend is also observed in Matrix Metalloproteinase-9 (MMP-9; p?>?0.05). There were however no differences in clinical outcomes. Conclusions: Maximizing the dose of statin in patients waiting for cardiac surgery has measurable biological effects. There is evidence of less cardiac and renal damage. The use of preoperative statins and in particular, high dose preoperative statin therapy, may prove a useful new tool for optimal preparation of patients for cardiac surgery. Trial registration: EudraCT no. 2012-003396-20. Registered 05 November 2012 Twit Text FOAVip High dose statin prophylaxis in cardiopulmonary bypass related surgery: clinical utility ????J Cardiothorac Surg http://www.kidney.de/pget.php?&tw=1&pmid=28359339 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28359339 #FOAvip English Wikipedia <ref>{{Cite pmid|28359339}}</ref> High dose statin prophylaxis in cardiopulmonary bypass related surgery: clinical utility #MMPMID28359339 Chee YR; Watson RWG; McCarthy J; Chughtai JZ; Nölke L; Healy DG J Cardiothorac Surg 2017[]; 12 (ä): ä PMID28359339show ga Background: Previous studies from our group demonstrated the anti-inflammatory properties of statins on cardiopulmonary bypass (CPB), through inhibition of neutrophil transendothelial migration. We sought to determine the utility of preoperative statin on patients undergoing cardiac surgery, to investigate any moderating effects on the systemic inflammatory response (SIRS) with CPB, and to evaluate any clinical impact on our patients. Methods: This is a prospective, randomised controlled trial with national regulatory body approval. Eligible patients were already on oral statin therapy. They were then randomly assigned to either investigation arm (n?=?15, atorvastatin 80 mg for 2 weeks before surgery) or control arm (n?=?15, no change to current statin therapy). Blood and urine samples were collected at 3 timepoints. Postoperative clinical measures were documented. Results: Patients in the investigation arm have significantly lower troponin level (p?=?0.016), and lower level of urine neutrophil gelatinase-associated lipocalin (NGAL; p?=?0.002); thus demonstrating a lesser degree of cardiac and renal injury in these patients. Higher level of Interleukin-8 (IL-8) at baseline (p?=?0.036) and 4 h post cross-clamp removal (p?=?0.035) in the investiation arm. A similar trend is also observed in Matrix Metalloproteinase-9 (MMP-9; p?>?0.05). There were however no differences in clinical outcomes. Conclusions: Maximizing the dose of statin in patients waiting for cardiac surgery has measurable biological effects. There is evidence of less cardiac and renal damage. The use of preoperative statins and in particular, high dose preoperative statin therapy, may prove a useful new tool for optimal preparation of patients for cardiac surgery. Trial registration: EudraCT no. 2012-003396-20. Registered 05 November 2012 äHigh dose statin prophylaxis in cardiopulmonary bypass related surgery(epmc).pdf DeepDyve Pubget Overpricing