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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 J+AAPOS
2016 ; 20
(4
): 326-31
Nephropedia Template TP
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English Wikipedia
A pilot randomized clinical trial of intermittent occlusion therapy liquid
crystal glasses versus traditional patching for treatment of moderate unilateral
amblyopia
#MMPMID27418249
Wang J
; Neely DE
; Galli J
; Schliesser J
; Graves A
; Damarjian TG
; Kovarik J
; Bowsher J
; Smith HA
; Donaldson D
; Haider KM
; Roberts GJ
; Sprunger DT
; Plager DA
J AAPOS
2016[Aug]; 20
(4
): 326-31
PMID27418249
show ga
PURPOSE: To compare the effectiveness of intermittent occlusion therapy (IO
therapy) using liquid crystal glasses and continuous occlusion therapy using
traditional adhesive patches for treating amblyopia. METHODS: Children 3-8 years
of age with previously untreated, moderate, unilateral amblyopia (visual acuity
of 20/40 to 20/100 in the amblyopic eye) were enrolled in this randomized
controlled trial. Amblyopia was associated with strabismus, anisometropia, or
both. All subjects had worn any optimal refractive correction for at least
12 weeks without improvement. Subjects were randomized into two treatment groups:
a 4-hour IO therapy group with liquid crystal glasses (Amblyz), set at 30-second
opaque/transparent intervals (occluded 50% of wear time), and a 2-hour continuous
patching group (occluded 100% of wear time). For each patient, visual acuity was
measured using ATS-HOTV before and after 12 weeks of treatment. RESULTS: Data
from 34 patients were available for analysis. Amblyopic eye visual acuity
improvement from baseline was 0.15 ± 0.12 logMAR (95% CI, 0.09-0.15) in the IO
therapy group (n = 19) and 0.15 ± 0.11 logMAR (95% CI, 0.1-0.15) in the patching
group (n = 15). In both groups improvement was significant, but the difference
between groups was not (P = 0.73). No adverse effects were reported. CONCLUSIONS:
In this pilot study, IO therapy with liquid crystal glasses is not inferior to
adhesive patching and is a promising alternative treatment for children 3-8 years
of age with moderate amblyopia.