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10.1242/dev.146100 http://scihub22266oqcxt.onion/10.1242/dev.146100 C5374356!5374356!28232601     free     free     free Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Development 2017 ; 144 (5): 767-77 Nephropedia Template TP {{tp|p=28232601|t=2017. Severe pre-eclampsia is associated with alterations in cytotrophoblasts of the smooth chorion |pdf=|usr=}}{{28232601}} gab.com Text Severe pre-eclampsia is associated with alterations in cytotrophoblasts of the smooth chorion JO: Development http://www.kidney.de/pget.php?&tw=1&pmid=28232601 #FOAvip Pre-eclampsia (PE), which affects ?8% of first pregnancies, is associated with faulty placentation. Extravillous cytotrophoblasts (CTBs) fail to differentiate properly, contributing to shallow uterine invasion and deficient spiral artery remodeling. We studied the effects of severe PE (sPE) on the smooth chorion portion of the fetal membranes. The results showed a significant expansion of the CTB layer. The cells displayed enhanced expression of stage-specific antigens that extravillous CTBs normally upregulate as they exit the placenta. Transcriptomics revealed the dysregulated expression of many genes (e.g. placental proteins, markers of oxidative stress). We confirmed an sPE-related increase in production of PAPPA1, which releases IGF1 from its binding protein. IGF1 enhanced proliferation of smooth chorion CTBs, a possible explanation for expansion of this layer, which may partially compensate for the placental deficits. Twit Text FOAVip Severe pre-eclampsia is associated with alterations in cytotrophoblasts of the smooth chorion ????Development http://www.kidney.de/pget.php?&tw=1&pmid=28232601 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28232601 #FOAvip English Wikipedia <ref>{{Cite pmid|28232601}}</ref> Severe pre-eclampsia is associated with alterations in cytotrophoblasts of the smooth chorion #MMPMID28232601 Garrido-Gomez T; Ona K; Kapidzic M; Gormley M; Simón C; Genbacev O; Fisher SJ Development 2017[Mar]; 144 (5): 767-77 PMID28232601show ga Pre-eclampsia (PE), which affects ?8% of first pregnancies, is associated with faulty placentation. Extravillous cytotrophoblasts (CTBs) fail to differentiate properly, contributing to shallow uterine invasion and deficient spiral artery remodeling. We studied the effects of severe PE (sPE) on the smooth chorion portion of the fetal membranes. The results showed a significant expansion of the CTB layer. The cells displayed enhanced expression of stage-specific antigens that extravillous CTBs normally upregulate as they exit the placenta. Transcriptomics revealed the dysregulated expression of many genes (e.g. placental proteins, markers of oxidative stress). We confirmed an sPE-related increase in production of PAPPA1, which releases IGF1 from its binding protein. IGF1 enhanced proliferation of smooth chorion CTBs, a possible explanation for expansion of this layer, which may partially compensate for the placental deficits. äSevere pre-eclampsia is associated with alterations in cytotrophoblast(epmc).pdf DeepDyve Pubget Overpricing