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10.1152/ajpendo.00337.2016 http://scihub22266oqcxt.onion/10.1152/ajpendo.00337.2016 C5374298!5374298!27894066     free     free     free Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Am+J+Physiol+Endocrinol+Metab 2017 ; 312 (3): E161-74 Nephropedia Template TP {{tp|p=27894066|t=2017. Obesity-associated extracellular mtDNA activates central TGF? pathway to cause blood pressure increase |pdf=|usr=}}{{27894066}} gab.com Text Obesity-associated extracellular mtDNA activates central TGF pathway to cause blood pressure increase JO: Am J Physiol Endocrinol Metab http://www.kidney.de/pget.php?&tw=1&pmid=27894066 #FOAvip Hypothalamic inflammation was recently found to mediate obesity-related hypertension, but the responsible upstream mediators remain unexplored. In this study, we show that dietary obesity is associated with extracellular release of mitochondrial DNA (mtDNA) into the cerebrospinal fluid and that central delivery of mtDNA mimics transforming growth factor-? (TGF?) excess to activate downstream signaling pathways. Physiological study reveals that central administration of mtDNA or TGF? is sufficient to cause hypertension in mice. Knockout of the TGF? receptor in proopiomelanocortin neurons counteracts the hypertensive effect of not only TGF? but also mtDNA excess, while the hypertensive action of central mtDNA can be blocked pharmacologically by a TGF? receptor antagonist or genetically by TGF? receptor knockout. Finally, we confirm that obesity-induced hypertension can be reversed through central treatment with TGF? receptor antagonist. In conclusion, circulating mtDNA in the brain employs neural TGF? pathway to mediate a central inflammatory mechanism of obesity-related hypertension. Twit Text FOAVip Obesity-associated extracellular mtDNA activates central TGF pathway to cause blood pressure increase ????Am J Physiol Endocrinol Metab http://www.kidney.de/pget.php?&tw=1&pmid=27894066 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27894066 #FOAvip English Wikipedia <ref>{{Cite pmid|27894066}}</ref> Obesity-associated extracellular mtDNA activates central TGF? pathway to cause blood pressure increase #MMPMID27894066 Alé A; Zhang Y; Han C; Cai D Am J Physiol Endocrinol Metab 2017[Mar]; 312 (3): E161-74 PMID27894066show ga Hypothalamic inflammation was recently found to mediate obesity-related hypertension, but the responsible upstream mediators remain unexplored. In this study, we show that dietary obesity is associated with extracellular release of mitochondrial DNA (mtDNA) into the cerebrospinal fluid and that central delivery of mtDNA mimics transforming growth factor-? (TGF?) excess to activate downstream signaling pathways. Physiological study reveals that central administration of mtDNA or TGF? is sufficient to cause hypertension in mice. Knockout of the TGF? receptor in proopiomelanocortin neurons counteracts the hypertensive effect of not only TGF? but also mtDNA excess, while the hypertensive action of central mtDNA can be blocked pharmacologically by a TGF? receptor antagonist or genetically by TGF? receptor knockout. Finally, we confirm that obesity-induced hypertension can be reversed through central treatment with TGF? receptor antagonist. In conclusion, circulating mtDNA in the brain employs neural TGF? pathway to mediate a central inflammatory mechanism of obesity-related hypertension. äObesity-associated extracellular mtDNA activates central TGF? pathway (epmc).pdf DeepDyve Pubget Overpricing