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10.3748/wjg.v23.i12.2106 http://scihub22266oqcxt.onion/10.3748/wjg.v23.i12.2106 C5374123!5374123!28405139     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       World+J+Gastroenterol 2017 ; 23 (12): 2106-23 Nephropedia Template TP {{tp|p=28405139|t=2017. Regulation of intestinal permeability: The role of proteases |pdf=|usr=}}{{28405139}} gab.com Text Regulation of intestinal permeability: The role of proteases JO: World J Gastroenterol http://www.kidney.de/pget.php?&tw=1&pmid=28405139 #FOAvip The gastrointestinal barrier is - with approximately 400 m2 - the human body?s largest surface separating the external environment from the internal milieu. This barrier serves a dual function: permitting the absorption of nutrients, water and electrolytes on the one hand, while limiting host contact with noxious luminal antigens on the other hand. To maintain this selective barrier, junction protein complexes seal the intercellular space between adjacent epithelial cells and regulate the paracellular transport. Increased intestinal permeability is associated with and suggested as a player in the pathophysiology of various gastrointestinal and extra-intestinal diseases such as inflammatory bowel disease, celiac disease and type 1 diabetes. The gastrointestinal tract is exposed to high levels of endogenous and exogenous proteases, both in the lumen and in the mucosa. There is increasing evidence to suggest that a dysregulation of the protease/antiprotease balance in the gut contributes to epithelial damage and increased permeability. Excessive proteolysis leads to direct cleavage of intercellular junction proteins, or to opening of the junction proteins via activation of protease activated receptors. In addition, proteases regulate the activity and availability of cytokines and growth factors, which are also known modulators of intestinal permeability. This review aims at outlining the mechanisms by which proteases alter the intestinal permeability. More knowledge on the role of proteases in mucosal homeostasis and gastrointestinal barrier function will definitely contribute to the identification of new therapeutic targets for permeability-related diseases. Twit Text FOAVip Regulation of intestinal permeability: The role of proteases ????World J Gastroenterol http://www.kidney.de/pget.php?&tw=1&pmid=28405139 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28405139 #FOAvip English Wikipedia <ref>{{Cite pmid|28405139}}</ref> Regulation of intestinal permeability: The role of proteases #MMPMID28405139 Van Spaendonk H; Ceuleers H; Witters L; Patteet E; Joossens J; Augustyns K; Lambeir AM; De Meester I; De Man JG; De Winter BY World J Gastroenterol 2017[Mar]; 23 (12): 2106-23 PMID28405139show ga The gastrointestinal barrier is - with approximately 400 m2 - the human body?s largest surface separating the external environment from the internal milieu. This barrier serves a dual function: permitting the absorption of nutrients, water and electrolytes on the one hand, while limiting host contact with noxious luminal antigens on the other hand. To maintain this selective barrier, junction protein complexes seal the intercellular space between adjacent epithelial cells and regulate the paracellular transport. Increased intestinal permeability is associated with and suggested as a player in the pathophysiology of various gastrointestinal and extra-intestinal diseases such as inflammatory bowel disease, celiac disease and type 1 diabetes. The gastrointestinal tract is exposed to high levels of endogenous and exogenous proteases, both in the lumen and in the mucosa. There is increasing evidence to suggest that a dysregulation of the protease/antiprotease balance in the gut contributes to epithelial damage and increased permeability. Excessive proteolysis leads to direct cleavage of intercellular junction proteins, or to opening of the junction proteins via activation of protease activated receptors. In addition, proteases regulate the activity and availability of cytokines and growth factors, which are also known modulators of intestinal permeability. This review aims at outlining the mechanisms by which proteases alter the intestinal permeability. More knowledge on the role of proteases in mucosal homeostasis and gastrointestinal barrier function will definitely contribute to the identification of new therapeutic targets for permeability-related diseases. äRegulation of intestinal permeability: The role of proteases (epmc).pdf DeepDyve Pubget Overpricing